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Nanomaterials 2017, 7(2), 43; doi:10.3390/nano7020043

Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials

1
Department of Organic Chemistry, Biochemistry and Catalysis, University of Bucharest, 90-92 Panduri, 050663 Bucharest, Romania
2
Microbiology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Way, 060101 Bucharest, Romania
3
Research Institute of the University of Bucharest-ICUB, 91–95 Spl. Independentei, 050095 Bucharest, Romania
4
Romanian Academy, Ştefan S. Nicolau Institute of Virology—IVN, 285 Mihai Bravu Avenue, Sector 3, PO 77, PO Box 201, 030304 Bucharest, Romania
5
Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania
6
National Institute of Materials Physics, Laboratory of Atomic Structures and Defects in Advanced Materials, Atomistilor 105 bis, 077125 Magurele, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Nann
Received: 12 December 2016 / Revised: 28 January 2017 / Accepted: 7 February 2017 / Published: 16 February 2017
View Full-Text   |   Download PDF [1956 KB, uploaded 16 February 2017]   |  

Abstract

Water soluble gold nanoparticles protected by lipoic acid were obtained and further functionalized by standard coupling reaction with 1-naphtylamine, 4-aminoantipyrine, and 4′-aminobenzo-15-crown-5 ether. Derivatives of lipoic acid with 1-naphtylamine, 4-aminoantipyrine, and 4′-aminobenzo-15-crown-5 ether were also obtained and characterized. All these were tested for their antimicrobial activity, as well as for their influence on mammalian cell viability and cellular cycle. In all cases a decreased antimicrobial activity of the obtained bioactive nanoparticles was observed as compared with the organic compounds, proving that a possible inactivation of the bioactive groups could occur during functionalization. However, both the gold nanoparticles as well as the functionalized bioactive nanosystems proved to be biocompatible at concentrations lower than 50 µg/mL, as revealed by the cellular viability and cell cycle assay, demonstrating their potential for the development of novel antimicrobial agents. View Full-Text
Keywords: gold nanoparticles; lipoic acid; thioctic acid; antimicrobial; cytotoxicity; cellular cycle gold nanoparticles; lipoic acid; thioctic acid; antimicrobial; cytotoxicity; cellular cycle
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Turcu, I.; Zarafu, I.; Popa, M.; Chifiriuc, M.C.; Bleotu, C.; Culita, D.; Ghica, C.; Ionita, P. Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials. Nanomaterials 2017, 7, 43.

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