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Nanomaterials 2016, 6(7), 133;

Nanomaterials for Cardiac Myocyte Tissue Engineering

Department of Mechanical and Aerospace Engineering, California State University, Long Beach, Long Beach, CA 90840, USA
Deparment of Mechanical Engineering, Brigham Young University-Idaho, Rexburg, ID 83460, USA
Department of Biomedical Engineering, California State University, Long Beach, Long Beach, CA 90840, USA
International Research Center for Translational Orthopaedics, Soochow University, Suzhou 215006, China
Author to whom correspondence should be addressed.
Academic Editor: Ilaria Armentano
Received: 26 April 2016 / Revised: 11 July 2016 / Accepted: 12 July 2016 / Published: 19 July 2016
(This article belongs to the Special Issue Nanomaterials for Tissue Engineering)
View Full-Text   |   Download PDF [5806 KB, uploaded 19 July 2016]   |  


Since their synthesizing introduction to the research community, nanomaterials have infiltrated almost every corner of science and engineering. Over the last decade, one such field has begun to look at using nanomaterials for beneficial applications in tissue engineering, specifically, cardiac tissue engineering. During a myocardial infarction, part of the cardiac muscle, or myocardium, is deprived of blood. Therefore, the lack of oxygen destroys cardiomyocytes, leaving dead tissue and possibly resulting in the development of arrhythmia, ventricular remodeling, and eventual heart failure. Scarred cardiac muscle results in heart failure for millions of heart attack survivors worldwide. Modern cardiac tissue engineering research has developed nanomaterial applications to combat heart failure, preserve normal heart tissue, and grow healthy myocardium around the infarcted area. This review will discuss the recent progress of nanomaterials for cardiovascular tissue engineering applications through three main nanomaterial approaches: scaffold designs, patches, and injectable materials. View Full-Text
Keywords: tissue engineering; nanomaterials; cardiac infarction; scaffold; patch; injectable tissue engineering; nanomaterials; cardiac infarction; scaffold; patch; injectable

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Amezcua, R.; Shirolkar, A.; Fraze, C.; Stout, D.A. Nanomaterials for Cardiac Myocyte Tissue Engineering. Nanomaterials 2016, 6, 133.

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