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Nanomaterials 2016, 6(2), 24; doi:10.3390/nano6020024

A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles

1
Department of Chemistry and Biological Engineering, University of Science and Technology, Beijing 100083, China
2
Peking University People’s Hospital, Beijing 100083, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Yoshihiro Ito
Received: 15 December 2015 / Revised: 4 January 2016 / Accepted: 5 January 2016 / Published: 22 January 2016
(This article belongs to the Special Issue Nanostructured Biosensors 2016)
View Full-Text   |   Download PDF [1976 KB, uploaded 22 January 2016]   |  

Abstract

In this paper, highly purified and stable gold nanoparticle (AuNP) dimers connected at the two ends of DNA linkage were prepared by a versatile method. A nanostructured, surface-enhanced Raman scattering (SERS) switching sensor system was fabricated based on the controlled organization of gold nanoparticles (AuNPs) by a DNA nanomachine through the controlled formation/deformation of SERS “hotspots”. This strategy not only opens opportunities in the precise engineering of gap distances in gold-gold nanostructures in a highly controllable and reproducible fashion, but also provides a unique ability to research the origin of SERS and sequence-specific DNA detection. View Full-Text
Keywords: molecular beacon sensors; switch; self-assembly; surface-enhanced Raman scattering (SERS); gold nanoparticles molecular beacon sensors; switch; self-assembly; surface-enhanced Raman scattering (SERS); gold nanoparticles
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Li, Y.; Cheng, Y.; Xu, L.; Du, H.; Zhang, P.; Wen, Y.; Zhang, X. A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles. Nanomaterials 2016, 6, 24.

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