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Nanomaterials 2016, 6(12), 225; doi:10.3390/nano6120225

Titanium Dioxide Nanoparticle-Biomolecule Interactions Influence Oral Absorption

1
Division of Applied Food System, Major of Food Science and Technology, Seoul Women’s University, Seoul 01797, Korea
2
Department of Chemistry and Medical Chemistry, Yonsei University, Wonju, Gangwondo 26493, Korea
3
Seoul Institute, National Forensic Service, 139, Jiyang-ro, Yangcheon-gu, Seoul 08036, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Eleonore Fröhlich
Received: 19 October 2016 / Revised: 14 November 2016 / Accepted: 21 November 2016 / Published: 29 November 2016
(This article belongs to the Special Issue Cytotoxicity of Nanoparticles)
View Full-Text   |   Download PDF [3601 KB, uploaded 29 November 2016]   |  

Abstract

Titanium dioxide (TiO2) nanoparticles (NPs) have been widely applied in various industrial fields, such as electronics, packaging, food, and cosmetics. Accordingly, concerns about the potential toxicity of TiO2 NPs have increased. In order to comprehend their in vivo behavior and potential toxicity, we must evaluate the interactions between TiO2 NPs and biomolecules, which can alter the physicochemical properties and the fate of NPs under physiological conditions. In the present study, in vivo solubility, oral absorption, tissue distribution, and excretion kinetics of food grade TiO2 (f-TiO2) NPs were evaluated following a single-dose oral administration to rats and were compared to those of general grade TiO2 (g-TiO2) NPs. The effect of the interactions between the TiO2 NPs and biomolecules, such as glucose and albumin, on oral absorption was also investigated, with the aim of determining the surface interactions between them. The intestinal transport pathway was also assessed using 3-dimensional culture systems. The results demonstrate that slightly higher oral absorption of f-TiO2 NPs compared to g-TiO2 NPs could be related to their intestinal transport mechanism by microfold (M) cells, however, most of the NPs were eliminated through the feces. Moreover, the biokinetics of f-TiO2 NPs was highly dependent on their interaction with biomolecules, and the dispersibility was affected by modified surface chemistry. View Full-Text
Keywords: titanium dioxide; interaction; biomolecule; oral absorption; intestinal transport titanium dioxide; interaction; biomolecule; oral absorption; intestinal transport
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Jo, M.-R.; Yu, J.; Kim, H.-J.; Song, J.H.; Kim, K.-M.; Oh, J.-M.; Choi, S.-J. Titanium Dioxide Nanoparticle-Biomolecule Interactions Influence Oral Absorption. Nanomaterials 2016, 6, 225.

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