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Nanomaterials 2015, 5(4), 2231-2248;

Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge

Department of Physical Chemistry, Faculty of Pharmacy, University of Barcelona and Institute of Nanoscience and Nanotechnology (IN2UB), Avda. Joan XXIII, 08028 Barcelona, Spain
Author to whom correspondence should be addressed.
Academic Editor: Yurii K. Gun'ko
Received: 29 October 2015 / Revised: 25 November 2015 / Accepted: 8 December 2015 / Published: 11 December 2015
(This article belongs to the Special Issue Nanoparticles in Theranostics)
View Full-Text   |   Download PDF [1539 KB, uploaded 11 December 2015]   |  


The blood-brain barrier is a physical and physiological barrier that protects the brain from toxic substances within the bloodstream and helps maintain brain homeostasis. It also represents the main obstacle in the treatment of many diseases of the central nervous system. Among the different approaches employed to overcome this barrier, the use of nanoparticles as a tool to enhance delivery of therapeutic molecules to the brain is particularly promising. There is special interest in the use of magnetic nanoparticles, as their physical characteristics endow them with additional potentially useful properties. Following systemic administration, a magnetic field applied externally can mediate the capacity of magnetic nanoparticles to permeate the blood-brain barrier. Meanwhile, thermal energy released by magnetic nanoparticles under the influence of radiofrequency radiation can modulate blood-brain barrier integrity, increasing its permeability. In this review, we present the strategies that use magnetic nanoparticles, specifically iron oxide nanoparticles, to enhance drug delivery to the brain. View Full-Text
Keywords: magnetic nanoparticles; IONs; blood-brain barrier magnetic nanoparticles; IONs; blood-brain barrier

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Busquets, M.A.; Espargaró, A.; Sabaté, R.; Estelrich, J. Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge. Nanomaterials 2015, 5, 2231-2248.

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