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Nanomaterials 2014, 4(3), 741-765; doi:10.3390/nano4030741

Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design

CNRS UMR 8612 Institut Galien Paris-Sud, Paris-Sud 11 University, 92290 Châtenay-Malabry, France
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Received: 13 June 2014 / Revised: 28 July 2014 / Accepted: 28 July 2014 / Published: 20 August 2014
(This article belongs to the Special Issue Self-Assembled Nanomaterials)
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Abstract

A variety of cyclodextrin-based molecular structures, with substitutions of either primary or secondary faces of the natural oligosaccharide macrocycles of α-, β-, or γ-cyclodextrins, have been designed towards innovative applications of self-assembled cyclodextrin nanomaterials. Amphiphilic cyclodextrins have been obtained by chemical or enzymatic modifications of their macrocycles using phospholipidyl, peptidolipidyl, cholesteryl, and oligo(ethylene oxide) anchors as well as variable numbers of grafted hydrophobic hydrocarbon or fluorinated chains. These novel compounds may self-assemble in an aqueous medium into different types of supramolecular nanoassemblies (vesicles, micelles, nanorods, nanospheres, and other kinds of nanoparticles and liquid crystalline structures). This review discusses the supramolecular nanoarchitectures, which can be formed by amphiphilic cyclodextrin derivatives in mixtures with other molecules (phospholipids, surfactants, and olygonucleotides). Biomedical applications are foreseen for nanoencapsulation of drug molecules in the hydrophobic interchain volumes and nanocavities of the amphiphilic cyclodextrins (serving as drug carriers or pharmaceutical excipients), anticancer phototherapy, gene delivery, as well as for protection of instable active ingredients through inclusion complexation in nanostructured media. View Full-Text
Keywords: amphiphilic cyclodextrins; self-assembly; cyclodextrin nanoassemblies; mixed supramolecular cyclodextrin materials; nanoparticles; nanoencapsulation; gene and drug delivery amphiphilic cyclodextrins; self-assembly; cyclodextrin nanoassemblies; mixed supramolecular cyclodextrin materials; nanoparticles; nanoencapsulation; gene and drug delivery
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Zerkoune, L.; Angelova, A.; Lesieur, S. Nano-Assemblies of Modified Cyclodextrins and Their Complexes with Guest Molecules: Incorporation in Nanostructured Membranes and Amphiphile Nanoarchitectonics Design. Nanomaterials 2014, 4, 741-765.

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