Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging

doi:10.3390/nano2010001

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Nanomaterials 2012, 2(1), 1-14; doi:10.3390/nano2010001

Article

Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging

Kathryn M. L. Taylor-Pashow^1,†, Joseph Della Rocca^2,† and Wenbin Lin^2,*

¹ Savannah River National Laboratory, Savannah River Site, Bldg. 773-A, Aiken, SC 29808, USA ² Department of Chemistry, CB #3290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA ^† These authors contribute equally to this work.

* Author to whom correspondence should be addressed.

Received: 7 November 2011; in revised form: 15 December 2011 / Accepted: 20 December 2011 / Published: 27 December 2011

(This article belongs to the Special Issue From Molecules to Nanomaterials)

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Abstract: Several mesoporous silica nanoparticle (MSN) contrast agents have been synthesized using a co-condensation method to incorporate two different Gd³⁺ complexes at very high loadings (15.5–28.8 wt %). These MSN contrast agents, with an MCM-41 type pore structure, were characterized using a variety of methods including SEM and TEM, nitrogen adsorption measurements, thermogravimetric analysis (TGA), direct current plasma (DCP) spectroscopy, and powder X-ray diffraction (PXRD). The magnetic resonance (MR) relaxivities of these contrast agents were determined using a 3 T MR scanner. The r₁ relaxivities of these nanoparticles range from 4.1 to 8.4 mM⁻¹s⁻¹ on a per Gd basis. Additionally, the MSN particles were functionalized with an organic fluorophore and cancer cell targeting peptide to allow for demonstration of both the optical and MR contrast enhancing capabilities in vitro.

Keywords: mesoporous silica nanoparticle; MRI contrast agent; Gd³⁺ contrast agent; multimodal imaging

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Cite This Article

MDPI and ACS Style

Taylor-Pashow, K.M.L.; Rocca, J.D.; Lin, W. Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging. Nanomaterials 2012, 2, 1-14.

AMA Style

Taylor-Pashow KML, Rocca JD, Lin W. Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging. Nanomaterials. 2012; 2(1):1-14.

Chicago/Turabian Style

Taylor-Pashow, Kathryn M. L.; Rocca, Joseph Della; Lin, Wenbin. 2012. "Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging." Nanomaterials 2, no. 1: 1-14.

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