Next Article in Journal / Special Issue
Accurate Size and Size-Distribution Determination of Polystyrene Latex Nanoparticles in Aqueous Medium Using Dynamic Light Scattering and Asymmetrical Flow Field Flow Fractionation with Multi-Angle Light Scattering
Previous Article in Journal
Quantum Dot Sensitized Photoelectrodes
Previous Article in Special Issue
Fabrication of Size-Tunable Metallic Nanoparticles Using Plasmid DNA as a Biomolecular Reactor
Nanomaterials 2012, 2(1), 1-14; doi:10.3390/nano2010001
Article

Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging

1,†
,
2,†
 and
2,*
Received: 7 November 2011 / Revised: 15 December 2011 / Accepted: 20 December 2011 / Published: 27 December 2011
(This article belongs to the Special Issue From Molecules to Nanomaterials)
View Full-Text   |   Download PDF [527 KB, uploaded 27 December 2011]   |   Browse Figures

Abstract

Several mesoporous silica nanoparticle (MSN) contrast agents have been synthesized using a co-condensation method to incorporate two different Gd3+ complexes at very high loadings (15.5–28.8 wt %). These MSN contrast agents, with an MCM-41 type pore structure, were characterized using a variety of methods including SEM and TEM, nitrogen adsorption measurements, thermogravimetric analysis (TGA), direct current plasma (DCP) spectroscopy, and powder X-ray diffraction (PXRD). The magnetic resonance (MR) relaxivities of these contrast agents were determined using a 3 T MR scanner. The r1 relaxivities of these nanoparticles range from 4.1 to 8.4 mM−1s−1 on a per Gd basis. Additionally, the MSN particles were functionalized with an organic fluorophore and cancer cell targeting peptide to allow for demonstration of both the optical and MR contrast enhancing capabilities in vitro.
Keywords: mesoporous silica nanoparticle; MRI contrast agent; Gd3+ contrast agent; multimodal imaging mesoporous silica nanoparticle; MRI contrast agent; Gd3+ contrast agent; multimodal imaging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplement

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Taylor-Pashow, K.M.L.; Rocca, J.D.; Lin, W. Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging. Nanomaterials 2012, 2, 1-14.

View more citation formats

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert