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J. Funct. Biomater. 2018, 9(2), 36; https://doi.org/10.3390/jfb9020036

Encapsulation and Characterization of Gentamicin Sulfate in the Collagen Added Electrospun Nanofibers for Skin Regeneration

1
Department of Chemistry, Kulliyyah of Science, International Islamic University of Malaysia Kuantan Campus, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia
2
Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur 56000, Malaysia
3
Institute for Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra d’Oltremare, Pad. 20, V. le Kennedy 54, 80125 Naples, Italy
*
Authors to whom correspondence should be addressed.
Received: 22 March 2018 / Revised: 26 April 2018 / Accepted: 7 May 2018 / Published: 18 May 2018
(This article belongs to the Special Issue Biodegradable Materials for Drug Delivery)
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Abstract

In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diffusing as skin substitutes. Indeed, engineered skin grafts or analogues frequently play an important role in the treatment of chronic skin wounds, by supporting the regeneration of newly formed tissue, and at the same time preventing infections during the long-term treatment. In this context, natural proteins such as collagen—natively present in the skin tissue—embedded in synthetic polymers (i.e., PCL) allow the development of micro-structured matrices able to mimic the functions and to structure of the surrounding extracellular matrix. Moreover, the encapsulation of drugs, such as gentamicin sulfate, also improves the bioactivity of nanofibers, due to the efficient loading and a controlled drug release towards the site of interest. Herein, we have done a preliminary investigation on the capability of gentamicin sulfate, loaded into collagen-added nanofibers, for the controlled release in local infection treatments. Experimental studies have demonstrated that collagen added fibers can be efficaciously used to administrate gentamicin for 72 h without any toxic in vitro response, thus emerging as a valid candidate for the therapeutic treatment of infected wounds. View Full-Text
Keywords: collagen; gentamicin; nanofibers; controlled release; skin regeneration collagen; gentamicin; nanofibers; controlled release; skin regeneration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Abdul Khodir, W.K.W.; Abdul Razak, A.H.; Ng, M.H.; Guarino, V.; Susanti, D. Encapsulation and Characterization of Gentamicin Sulfate in the Collagen Added Electrospun Nanofibers for Skin Regeneration. J. Funct. Biomater. 2018, 9, 36.

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