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J. Funct. Biomater. 2018, 9(2), 29; https://doi.org/10.3390/jfb9020029

Novel Chlorhexidine-Loaded Polymeric Nanoparticles for Root Canal Treatment

1
Department of Bioengineering, University of Texas at Dallas, 800 W Campbell, Richardson, TX 75080, USA
2
Department of Conservative Dentistry, Dental School, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2492, 90460-001 Porto Alegre, Brazil
3
Department of Biological Sciences University of Texas at Dallas, 800 W Campbell, Richardson, TX 75080, USA
4
Department of Chemistry, University of Texas at Dallas, 800 W Campbell, Richardson, TX 75080, USA
*
Author to whom correspondence should be addressed.
Received: 14 March 2018 / Revised: 4 April 2018 / Accepted: 13 April 2018 / Published: 17 April 2018
(This article belongs to the Special Issue Dental Implant Materials and Biomaterials)
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Abstract

Persistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, which is aimed at improving the disinfection of the root canal system. Chlorhexidine digluconate was encapsulated inside polymeric self-assembled TNPs. These were self-assembled through water-in-oil emulsion from poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA), a di-block copolymer, with one hydrophilic segment and another hydrophobic. The resulting TNPs were physicochemically characterized and their antimicrobial effectiveness was evaluated against Enterococcus faecalis using a broth inhibition method. The hydrophilic interior of the TNPs successfully entrapped chlorhexidine digluconate. The resulting TNPs had particle size ranging from 140–295 nm, with adequate encapsulation efficiency, and maintained inhibition of bacteria over 21 days. The delivery of antibacterial irrigants throughout the dentinal matrix by employing the TNP system described in this work may be an effective alternative to improve root canal disinfection. View Full-Text
Keywords: chlorhexidine; dentin permeability; dentin tubules; drug encapsulation; polymeric nanoparticles; poly(ethylene glycol)-b-poly(lactic acid) chlorhexidine; dentin permeability; dentin tubules; drug encapsulation; polymeric nanoparticles; poly(ethylene glycol)-b-poly(lactic acid)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Quiram, G.; Montagner, F.; Palmer, K.L.; Stefan, M.C.; Washington, K.E.; Rodrigues, D.C. Novel Chlorhexidine-Loaded Polymeric Nanoparticles for Root Canal Treatment. J. Funct. Biomater. 2018, 9, 29.

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