Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B12 Levels in Serum
AbstractThe administration of biological compounds that optimize health benefits is an ever-evolving therapeutic goal. Pharmaceutical and other adjunctive biological compounds have been administered via many different routes in order to produce a systemic pharmacological effect. The article summarizes the findings from an Australian comparative study in adults administered vitamin B12 through different oral delivery platforms. A total of 16 subjects (9 males, 7 females) voluntarily partook in a comparative clinical study of five different vitamin B12 formulations across a six-month period, completing 474 person-hours of cumulative contribution, that was equivalent to an n = 60 participation. A nanoparticle delivered vitamin B12 through a NanoCelle platform was observed to be significantly (p < 0.05) better absorbed than all other dose equivalent platforms (i.e., tablets, emulsions, or liposomes) from baseline to 1, 3, and 6 h of the study period. The nanoparticle platform delivered vitamin B12 demonstrated an enhanced and significant absorption profile as exemplified by rapid systemic detection (i.e., 1 h from baseline) when administered to the oro-buccal mucosa with no reports of any adverse events of toxicity. The nanoparticle formulation of methylcobalamin (1000 µg/dose in 0.3 mL volume) showed bioequivalence only with a chewable-dissolvable tablet that administered a five times higher dose of methylcobalamin (5000 µg) per tablet. This study has demonstrated that an active metabolite embedded in a functional biomaterial (NanoCelle) may constitute a drug delivery method that can better access the circulatory system. View Full-Text
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Vitetta, L.; Zhou, J.; Manuel, R.; Dal Forno, S.; Hall, S.; Rutolo, D. Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B12 Levels in Serum. J. Funct. Biomater. 2018, 9, 12.
Vitetta L, Zhou J, Manuel R, Dal Forno S, Hall S, Rutolo D. Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B12 Levels in Serum. Journal of Functional Biomaterials. 2018; 9(1):12.Chicago/Turabian Style
Vitetta, Luis; Zhou, Joyce; Manuel, Rachel; Dal Forno, Serena; Hall, Sean; Rutolo, David. 2018. "Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B12 Levels in Serum." J. Funct. Biomater. 9, no. 1: 12.
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