Next Article in Journal
Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis
Previous Article in Journal
Orthodontic Metallic Lingual Brackets: The Dark Side of the Moon of Bond Failures?
Article Menu

Export Article

Open AccessFeature PaperArticle
J. Funct. Biomater. 2017, 8(3), 28; doi:10.3390/jfb8030028

The Feasibility and Functional Performance of Ternary Borate-Filled Hydrophilic Bone Cements: Targeting Therapeutic Release Thresholds for Strontium

1
School of Biomedical Engineering, Dalhousie University, Halifax, NS B3H 1X7, Canada
2
Department of Dental Clinical Sciences, Dalhousie University, Halifax, NS B3H 1X7, Canada
3
Department Applied Oral Sciences, Dalhousie University, Halifax, NS B3H 1X7, Canada
*
Author to whom correspondence should be addressed.
Received: 31 May 2017 / Revised: 7 July 2017 / Accepted: 10 July 2017 / Published: 14 July 2017
(This article belongs to the Special Issue Recent Advances in Bioactive Glasses)
View Full-Text   |   Download PDF [3004 KB, uploaded 14 July 2017]   |  

Abstract

We examine the feasibility and functionality of hydrophilic modifications to a borate glass reinforced resin composite; with the objective of meeting and maintaining therapeutic thresholds for Sr release over time, as a potential method of incorporating antiosteoporotic therapy into a vertebroplasty material. Fifteen composites were formulated with the hydrophilic agent hydroxyl ethyl methacrylate (HEMA, 15, 22.5, 30, 37.5 or 45 wt% of resin phase) and filled with a borate glass (55, 60 or 65 wt% of total cement) with known Sr release characteristics. Cements were examined with respect to degree of cure, water sorption, Sr release, and biaxial flexural strength over 60 days of incubation in phosphate buffered saline. While water sorption and glass degradation increased with increasing HEMA content, Sr release peaked with the 30% HEMA compositions, scanning electron microscope (SEM) imaging confirmed the surface precipitation of a Sr phosphate compound. Biaxial flexural strengths ranged between 16 and 44 MPa, decreasing with increased HEMA content. Degree of cure increased with HEMA content (42 to 81%), while no significant effect was seen on setting times (209 to 263 s). High HEMA content may provide a method of increasing monomer conversion without effect on setting reaction, providing sustained mechanical strength over 60 days. View Full-Text
Keywords: composite resin cement; bone cement; borate glass; strontium; therapeutic inorganic ions; hydroxyethyl methacrylate composite resin cement; bone cement; borate glass; strontium; therapeutic inorganic ions; hydroxyethyl methacrylate
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

MacDonald, K.; Price, R.B.; Boyd, D. The Feasibility and Functional Performance of Ternary Borate-Filled Hydrophilic Bone Cements: Targeting Therapeutic Release Thresholds for Strontium. J. Funct. Biomater. 2017, 8, 28.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top