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J. Funct. Biomater. 2017, 8(2), 18; doi:10.3390/jfb8020018

Cellular Morphology-Mediated Proliferation and Drug Sensitivity of Breast Cancer Cells

Advanced Polymeric Nanostructured Materials Engineering, Graduate School of Engineering, Toyota Technological Institute, 2-12-1 Hisakata, Tempaku, Nagoya 468 8511, Japan
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Academic Editor: Christine Knabe-Ducheyne
Received: 26 April 2017 / Revised: 12 May 2017 / Accepted: 26 May 2017 / Published: 6 June 2017
(This article belongs to the Special Issue Biodegradable Scaffolds)
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Abstract

The interpretation of the local microenvironment of the extracellular matrix for malignant tumor cells is in intimate relation with metastatic spread of cancer cells involving the associated issues of cellular proliferation and drug responsiveness. This study was aimed to assess the combination of both surface topographies (fiber alignments) and different stiffness of the polymeric substrates (poly(l-lactic acid) and poly(ε-caprolactone), PLLA and PCL, respectively) as well as collagen substrates (coat and gel) to elucidate the effect of the cellular morphology on cellular proliferation and drug sensitivities of two different types of breast cancer cells (MDA-MB-231 and MCF-7). The morphological spreading parameter (nucleus/cytoplasm area ratio) induced by the anthropogenic substrates has correlated intimately with the cellular proliferation and the drug sensitivity the half maximal inhibitory concentration (IC50) of cancer cells. This study demonstrated the promising results of the parameter for the evaluation of cancer cell malignancy. View Full-Text
Keywords: spreading parameter; cellular proliferation; drug sensitivity; substrates; cancer cells spreading parameter; cellular proliferation; drug sensitivity; substrates; cancer cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Domura, R.; Sasaki, R.; Ishikawa, Y.; Okamoto, M. Cellular Morphology-Mediated Proliferation and Drug Sensitivity of Breast Cancer Cells. J. Funct. Biomater. 2017, 8, 18.

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