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Open AccessFeature PaperArticle
J. Funct. Biomater. 2017, 8(2), 16; doi:10.3390/jfb8020016

Enhanced Osseointegration of a Modified Titanium Implant with Bound Phospho-Threonine: A Preliminary In Vivo Study

Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Francesco Puoci
Received: 27 February 2017 / Revised: 18 May 2017 / Accepted: 18 May 2017 / Published: 25 May 2017
(This article belongs to the Special Issue Journal of Functional Biomaterials: Feature Papers 2016)
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Abstract

Implant surface topography is a key factor in achieving osseointegration. l-Threonine can be chemically and stably bonded to titanium surfaces by phosphorylation. This study investigated the degree of in vivo osseointegration of an implant with a novel o-phospho-l-threonine (p-Thr)-binding surface. MC3T3-E1 cells were seeded on the p-Thr binding surface and machined surface disks, and initial cell attachment was evaluated. p-Thr-binding and machined surface implants were tested in vivo by implantation into the femurs of three male New Zealand white rabbits, and the osseointegration was assessed by measurement of removal torque (RT) and bone-implant contact (BIC) ratio. Initial cell attachment was greater for the p-Thr-binding than for the machined surface implant group (P < 0.05). In addition, RT and BIC values were higher for the p-Thr-binding surface than for the machined surface (P < 0.05). These results indicate that our implant with a p-Thr-binding surface can achieve enhanced osseointegration. View Full-Text
Keywords: surface topography; titanium surface modification; o-phospho-l-threonine surface topography; titanium surface modification; o-phospho-l-threonine
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MDPI and ACS Style

Okazaki, Y.; Doi, K.; Oki, Y.; Kobatake, R.; Abe, Y.; Tsuga, K. Enhanced Osseointegration of a Modified Titanium Implant with Bound Phospho-Threonine: A Preliminary In Vivo Study. J. Funct. Biomater. 2017, 8, 16.

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