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J. Funct. Biomater. 2016, 7(3), 27; doi:10.3390/jfb7030027

Synthesis and Characterization of Nanodiamond Reinforced Chitosan for Bone Tissue Engineering

Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada
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Academic Editor: Xuebin Yang
Received: 26 April 2016 / Revised: 17 August 2016 / Accepted: 22 August 2016 / Published: 15 September 2016
(This article belongs to the Special Issue Mechanical Properties of Tissue Engineering Scaffolds)
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Abstract

Multifunctional tissue scaffold material nanodiamond (ND)/chitosan (CS) composites with different diamond concentrations from 1 wt % to 5 wt % were synthesized through a solution casting method. The microstructure and mechanical properties of the composites were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and nanoindentation. Compared with pristine CS, the addition of ND resulted in a significant improvement of mechanical properties, including a 239%, 276%, 321%, 333%, and 343% increase in Young’s modulus and a 68%, 96%, 114%, 118%, and 127% increase in hardness when the ND amount was 1 wt %, 2 wt %, 3 wt %, 4 wt %, and 5 wt %, respectively. The strong interaction between ND surface groups and the chitosan matrix plays an important role in improving mechanical properties. View Full-Text
Keywords: nanodiamond; chitosan; scaffold; nanoindentation; DSC; MTT nanodiamond; chitosan; scaffold; nanoindentation; DSC; MTT
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Sun, Y.; Yang, Q.; Wang, H. Synthesis and Characterization of Nanodiamond Reinforced Chitosan for Bone Tissue Engineering. J. Funct. Biomater. 2016, 7, 27.

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