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J. Funct. Biomater. 2015, 6(3), 564-584; doi:10.3390/jfb6030564

Tubular Scaffold with Shape Recovery Effect for Cell Guide Applications

1
Division of Materials, Mechanics and Structures, Faculty of Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK
2
Physics Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
*
Authors to whom correspondence should be addressed.
Academic Editor: Francesco Puoci
Received: 2 March 2015 / Accepted: 2 July 2015 / Published: 10 July 2015
(This article belongs to the Special Issue Feature Papers)
View Full-Text   |   Download PDF [5060 KB, uploaded 10 July 2015]   |  

Abstract

Tubular scaffolds with aligned polylactic acid (PLA) fibres were fabricated for cell guide applications by immersing rolled PLA fibre mats into a polyvinyl acetate (PVAc) solution to bind the mats. The PVAc solution was also mixed with up to 30 wt % β-tricalcium phosphate (β-TCP) content. Cross-sectional images of the scaffold materials obtained via scanning electron microscopy (SEM) revealed the aligned fibre morphology along with a significant number of voids in between the bundles of fibres. The addition of β-TCP into the scaffolds played an important role in increasing the void content from 17.1% to 25.3% for the 30 wt % β-TCP loading, which was measured via micro-CT (µCT) analysis. Furthermore, µCT analyses revealed the distribution of aggregated β-TCP particles in between the various PLA fibre layers of the scaffold. The compressive modulus properties of the scaffolds increased from 66 MPa to 83 MPa and the compressive strength properties decreased from 67 MPa to 41 MPa for the 30 wt % β-TCP content scaffold. The scaffolds produced were observed to change into a soft and flexible form which demonstrated shape recovery properties after immersion in phosphate buffered saline (PBS) media at 37 °C for 24 h. The cytocompatibility studies (using MG-63 human osteosarcoma cell line) revealed preferential cell proliferation along the longitudinal direction of the fibres as compared to the control tissue culture plastic. The manufacturing process highlighted above reveals a simple process for inducing controlled cell alignment and varying porosity features within tubular scaffolds for potential tissue engineering applications. View Full-Text
Keywords: tubular scaffolds; PLA fibre; compressive modulus; shape recovery; cell proliferation tubular scaffolds; PLA fibre; compressive modulus; shape recovery; cell proliferation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hossain, K.M.Z.; Zhu, C.; Felfel, R.M.; Sharmin, N.; Ahmed, I. Tubular Scaffold with Shape Recovery Effect for Cell Guide Applications. J. Funct. Biomater. 2015, 6, 564-584.

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