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J. Funct. Biomater. 2015, 6(1), 104-142; doi:10.3390/jfb6010104

Chitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials

1
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan
2
Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan
3
Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, 4-101 Koyama-minami, Tottori 680-8550, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: R. Jayakumar
Received: 17 January 2015 / Revised: 6 March 2015 / Accepted: 6 March 2015 / Published: 13 March 2015
(This article belongs to the Special Issue Biomedical Applications of Chitin and Chitosan)
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Abstract

Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and chitosan have been developed, and their effects on wound healing have been evaluated. In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized. Moreover, the development of adhesive-based chitin and chitosan are also described. The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process. More recently, it is also indicate that some nano-based materials from chitin and chitosan are beneficial than chitin and chitosan for wound healing. Clinical applications of nano-based chitin and chitosan are also expected. View Full-Text
Keywords: chitin; chitosan; wound healing; chitin nanofiber; chitosan nanofiber; animal experiments; adhesive chitin; chitosan; wound healing; chitin nanofiber; chitosan nanofiber; animal experiments; adhesive
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Azuma, K.; Izumi, R.; Osaki, T.; Ifuku, S.; Morimoto, M.; Saimoto, H.; Minami, S.; Okamoto, Y. Chitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials. J. Funct. Biomater. 2015, 6, 104-142.

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