Next Article in Journal
HaCaT Keratinocytes Response on Antimicrobial Atelocollagen Substrates: Extent of Cytotoxicity, Cell Viability and Proliferation
Previous Article in Journal
Correction: Koh, L.B., et al. Epoxy Cross-Linked Collagen and Collagen-Laminin Peptide Hydrogels as Corneal Substitutes. J. Funct. Biomater. 2013, 4, 162-177
J. Funct. Biomater. 2014, 5(2), 29-42; doi:10.3390/jfb5020029
Article

Extracts from New Zealand Undaria pinnatifida Containing Fucoxanthin as Potential Functional Biomaterials against Cancer in Vitro

1,2
, 1,3
, 1,3
 and 1,2,3,*
1 School of Applied Sciences, Faculty of Health and Environment Sciences, Auckland University of Technology, Auckland 1142, New Zealand 2 Institute of Biomedical Technology, Auckland University of Technology, Auckland 1142, New Zealand 3 School of Interprofessional Health Studies, Faculty of Health and Environment Sciences, Auckland University of Technology, Auckland 1142, New Zealand
* Author to whom correspondence should be addressed.
Received: 28 December 2013 / Revised: 3 March 2014 / Accepted: 10 March 2014 / Published: 31 March 2014
View Full-Text   |   Download PDF [450 KB, 25 April 2014; original version 31 March 2014]   |   Browse Figures

Abstract

This study tested extracts from New Zealand seaweed Undaria pinnatifida containing fucoxanthin, in parallel with pure fucoxanthin, in nine human cancer cell lines, for anticancer activity. Growth inhibition effects of extracts from Undaria pinnatifida were found in all types of cancer cell lines in dose- and time- dependent manners. Cytotoxicity of fucoxanthin in three human non-cancer cell lines was also tested. Compared with pure fucoxanthin, our extracts containing low level of fucoxanthin were found to be more effective in inhibiting the growth of lung carcinoma, colon adenocarcinoma and neuroblastoma. Our results suggest that fucoxanthin is a functional biomaterial that may be used as a chemopreventive phytochemical or in combination chemotherapy. Furthermore, we show for the first time that some unknown compounds with potential selective anti-cancer effects may exist in extracts of New Zealand Undaria pinnatifida, and New Zealand Undaria pinnatifida could be used as a source for either functional biomaterial extraction or production of functional food.
Keywords: fucoxanthin; Undaria pinnatifida; anti-cancer; New Zealand seaweed; extract fucoxanthin; Undaria pinnatifida; anti-cancer; New Zealand seaweed; extract
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Wang, S.K.; Li, Y.; White, W.L.; Lu, J. Extracts from New Zealand Undaria pinnatifida Containing Fucoxanthin as Potential Functional Biomaterials against Cancer in Vitro. J. Funct. Biomater. 2014, 5, 29-42.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert