Next Article in Journal / Special Issue
Biocompatibility of Bacterial Cellulose Based Biomaterials
Previous Article in Journal
Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair
Previous Article in Special Issue
Mineralization Content Alters Osteogenic Responses of Bone Marrow Stromal Cells on Hydroxyapatite/Polycaprolactone Composite Nanofiber Scaffolds
J. Funct. Biomater. 2012, 3(4), 839-863; doi:10.3390/jfb3040839
Review

Building Biocompatible Hydrogels for Tissue Engineering of the Brain and Spinal Cord

1
, 2
, 2
 and 1,*
Received: 27 June 2012; Accepted: 24 October 2012 / Published: 15 November 2012
(This article belongs to the Special Issue Biocompatibility of Biomaterials)
View Full-Text   |   Download PDF [300 KB, uploaded 16 November 2012]
Abstract: Tissue engineering strategies employing biomaterials have made great progress in the last few decades. However, the tissues of the brain and spinal cord pose unique challenges due to a separate immune system and their nature as soft tissue. Because of this, neural tissue engineering for the brain and spinal cord may require re-establishing biocompatibility and functionality of biomaterials that have previously been successful for tissue engineering in the body. The goal of this review is to briefly describe the distinctive properties of the central nervous system, specifically the neuroimmune response, and to describe the factors which contribute to building polymer hydrogels compatible with this tissue. These factors include polymer chemistry, polymerization and degradation, and the physical and mechanical properties of the hydrogel. By understanding the necessities in making hydrogels biocompatible with tissue of the brain and spinal cord, tissue engineers can then functionalize these materials for repairing and replacing tissue in the central nervous system.
Keywords: brain; spinal cord; microglia; astrocytes; biocompatibility; hydrogel; tissue engineering brain; spinal cord; microglia; astrocytes; biocompatibility; hydrogel; tissue engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Aurand, E.R.; Wagner, J.; Lanning, C.; Bjugstad, K.B. Building Biocompatible Hydrogels for Tissue Engineering of the Brain and Spinal Cord. J. Funct. Biomater. 2012, 3, 839-863.

AMA Style

Aurand ER, Wagner J, Lanning C, Bjugstad KB. Building Biocompatible Hydrogels for Tissue Engineering of the Brain and Spinal Cord. Journal of Functional Biomaterials. 2012; 3(4):839-863.

Chicago/Turabian Style

Aurand, Emily R.; Wagner, Jennifer; Lanning, Craig; Bjugstad, Kimberly B. 2012. "Building Biocompatible Hydrogels for Tissue Engineering of the Brain and Spinal Cord." J. Funct. Biomater. 3, no. 4: 839-863.


J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert