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Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials
William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA
Department of Materials and Science Engineering, The Ohio State University, Columbus, OH 43210, USA
Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA
* Author to whom correspondence should be addressed.
Received: 15 June 2012; in revised form: 19 July 2012 / Accepted: 20 July 2012 / Published: 27 July 2012
Abstract: Hydrogels, electrospun fiber mats (EFMs), and their composites have been extensively studied for tissue engineering because of their physical and chemical similarity to native biological systems. However, while chemically similar, hydrogels and electrospun fiber mats display very different topographical features. Here, we examine the influence of surface topography and composition of hydrogels, EFMs, and hydrogel-EFM composites on cell behavior. Materials studied were composed of synthetic poly(ethylene glycol) (PEG) and poly(ethylene glycol)-poly(ε-caprolactone) (PEGPCL) hydrogels and electrospun poly(caprolactone) (PCL) and core/shell PCL/PEGPCL constituent materials. The number of adherent cells and cell circularity were most strongly influenced by the fibrous nature of materials (e.g., topography), whereas cell spreading was more strongly influenced by material composition (e.g., chemistry). These results suggest that cell attachment and proliferation to hydrogel-EFM composites can be tuned by varying these properties to provide important insights for the future design of such composite materials.
Keywords: hydrogels; electrospun fibers; cell attachment; nanotopography; composite materials
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Han, N.; Johnson, J.K.; Bradley, P.A.; Parikh, K.S.; Lannutti, J.J.; Winter, J.O. Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials. J. Funct. Biomater. 2012, 3, 497-513.
Han N, Johnson JK, Bradley PA, Parikh KS, Lannutti JJ, Winter JO. Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials. Journal of Functional Biomaterials. 2012; 3(3):497-513.
Han, Ning; Johnson, Jed K.; Bradley, Patrick A.; Parikh, Kunal S.; Lannutti, John J.; Winter, Jessica O. 2012. "Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials." J. Funct. Biomater. 3, no. 3: 497-513.