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Computation 2018, 6(1), 1; doi:10.3390/computation6010001

Developing Computational Geometry and Network Graph Models of Human Lymphatic System

1
Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow 119333, Russia
2
Lomonosov Moscow State University, Moscow 119991, Russia
3
Pavlov Institute of Physiology, Russian Academy of Sciences, Saint-Petersburg 119034, Russia
*
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 16 December 2017 / Accepted: 19 December 2017 / Published: 28 December 2017
(This article belongs to the Section Computational Biology)
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Abstract

The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative terms. Although it is a vital part of the circulatory and immune systems, the lymphatic system remains poorly investigated as a mathematical modeling object. Modeling of the lymphatic vessel network needs to be established using a systematic approach in order to advance the model-driven research of this important physiological system. In our study, we elucidate key general features underlying the 3D structural organization of the lymphatic system in order to develop computational geometry and network graph models of the human lymphatic system based on available anatomical data (from the PlasticBoy project), which provides an estimate of the structure of the lymphatic system, and to analyze the topological properties of the resulting models. View Full-Text
Keywords: lymphatic system; geometric model; computational algorithm; network graph; topological properties lymphatic system; geometric model; computational algorithm; network graph; topological properties
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Tretyakova, R.; Savinkov, R.; Lobov, G.; Bocharov, G. Developing Computational Geometry and Network Graph Models of Human Lymphatic System. Computation 2018, 6, 1.

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