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Challenges 2017, 8(2), 29; doi:10.3390/challe8020029

Diagnostics for Targeted NSCLC Therapy

Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten/Herdecke, Institut für Pathologie, D-51109 Cologne, Germany
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Received: 26 October 2017 / Revised: 16 November 2017 / Accepted: 17 November 2017 / Published: 20 November 2017
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Abstract

Despite an increasing number of molecular biomarkers identified in non-small cell lung cancer (NSCLC), the number of approved therapy options targeting these biomarkers remains limited. Although some biomarkers may influence the therapy outcome of a distinct drug and have been shown to be useful in phase 2 or 3 clinical studies, diagnostics of biomarkers without an approved drug available or a possible off-label use is currently too expensive for routine diagnostics in non-academic institutions. For this reason, the present review is intended to summarize the current state of the art of molecular diagnostics that is both available and could lead to therapy guidance in NSCLC courses. Thereby, economic aspects are taken into account in order to take up the cudgels for a more comprehensive, even if more expensive, diagnostic scheme that in turn may save enormous costs by reducing therapy costs. View Full-Text
Keywords: lung cancer; NSCLC; diagnostics lung cancer; NSCLC; diagnostics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Schildgen, V.; Nenadic, I.; Brockmann, M.; Schildgen, O. Diagnostics for Targeted NSCLC Therapy. Challenges 2017, 8, 29.

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