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J. Mar. Sci. Eng. 2018, 6(2), 33; https://doi.org/10.3390/jmse6020033

In Vitro Inhibition of Acetylcholinesterase, Alphaglucosidase, and Xanthine Oxidase by Bacteria Extracts from Coral Reef in Hainan, South China Sea

1
Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences (CATAS)-Hainan Key Laboratory of Banana Genetic Improvement, Haikou 570102, Hainan, China
2
Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, Guangdong, China
3
Programa de Ofidismo/Escorpionismo, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, 1226 Medellín, Colombia
*
Author to whom correspondence should be addressed.
Received: 18 February 2018 / Revised: 15 March 2018 / Accepted: 27 March 2018 / Published: 5 April 2018
(This article belongs to the Section Marine Biology)
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Abstract

Acetylcholinesterase is one of the most important enzymes in living organisms, which is responsible for the synapse cholinergic and other nervous processes. However, its inhibiting effects have proven to have pharmacological applications in the treatment of different diseases, as well as in the control of insect pests; thus, the search for inhibitors is a matter of interest for biomedical and agrochemical fields. Alzheimer’s is a progressive neurodegenerative disease, which can be seen as a wide degeneration of synapses, as well as neurons, in the cerebral cortex, hippocampus, and subcortical structures. Acetylcholinesterase inhibition is an important target for the management of Alzheimer’s. Additionally, diabetes mellitus is a chronic disease with clinical manifestation of hyperglycemia, due to the ineffective production of insulin that controls the level of blood glucose. Alphaglucosidaseinhibitors could retard the uptake of dietary carbohydrates and have shown significant therapeutic effects in clinical application. Fifty-five ethyl acetate extracts from nine bacterial families from Hainan (China) were evaluated to observe their acetylcholinesterase, alphaglucosidase, and xanthine oxidase inhibitory activity. Moreover, a screening of inhibitory activity against the pathogens fungi Fusarium oxysporum and Colletotrichum gloeosporioides was performed. The best acetylcholinesterase and alphaglucosidase inhibitory activity was shown by Vibrio neocaledonicus (98.95%). This is the first report of inhibition of both enzymes by ethyl acetate extract from this strain. View Full-Text
Keywords: Vibrionaceae; Vibrio neocaledonicus; acetylcholinesterase; alphaglucosidase; Colletotrichum gloeosporioides; Fusarium oxysporum Vibrionaceae; Vibrio neocaledonicus; acetylcholinesterase; alphaglucosidase; Colletotrichum gloeosporioides; Fusarium oxysporum
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Tan, L.; Guo, S.; Ma, F.; Chang, C.; Gómez-Betancur, I. In Vitro Inhibition of Acetylcholinesterase, Alphaglucosidase, and Xanthine Oxidase by Bacteria Extracts from Coral Reef in Hainan, South China Sea. J. Mar. Sci. Eng. 2018, 6, 33.

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