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J. Clin. Med. 2018, 7(8), 220;

Mitochondrial DNA Haplogroup JT is Related to Impaired Glycaemic Control and Renal Function in Type 2 Diabetic Patients

Service of Endocrinology, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain
Department of Biochemistry and Molecular and Cell Biology, University of Zaragoza, 50013 Zaragoza, Spain
Instituto de Investigación Sanitaria de Aragón (IIS Aragón), 50013 Zaragoza, Spain
Centro de Investigaciones Biomédicas En Red de Enfermedades Raras (CIBERER), 50013 Zaragoza, Spain
CIBERehd-Department of Pharmacology and Physiology, University of Valencia, 46010 Valencia, Spain
Fundación ARAID, 50018 Zaragoza, Spain
Authors to whom correspondence should be addressed.
Received: 17 July 2018 / Revised: 13 August 2018 / Accepted: 14 August 2018 / Published: 16 August 2018
(This article belongs to the Special Issue Type 2 Diabetes: Update on Pathophysiology and Treatment)
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The association between mitochondrial DNA (mtDNA) haplogroup and risk of type 2 diabetes (T2D) is undetermined and controversial. This study aims to evaluate the impact of the main mtDNA haplogroups on glycaemic control and renal function in a Spanish population of 303 T2D patients and 153 healthy controls. Anthropometrical and metabolic parameters were assessed and mtDNA haplogroup was determined in each individual. Distribution of the different haplogroups was similar in diabetic and healthy populations and, as expected, T2D patients showed poorer glycaemic control and renal function than controls. T2D patients belonging to the JT haplogroup (polymorphism m.4216T>C) displayed statistically significant higher levels of fasting glucose and HbA1c than those of the other haplogroups, suggesting a poorer glycaemic control. Furthermore, diabetic patients with the JT haplogroup showed a worse kidney function than those with other haplogroups, evident by higher levels of serum creatinine, lower estimated glomerular filtration rate (eGFR), and slightly higher (although not statistically significant) urinary albumin-to-creatinine ratio. Our results suggest that JT haplogroup (in particular, change at position 4216 of the mtDNA) is associated with poorer glycaemic control in T2D, which can trigger the development of diabetic nephropathy. View Full-Text
Keywords: type 2 diabetes mellitus; mitochondrial haplogroup; mtDNA; nephropathy; glycemic control type 2 diabetes mellitus; mitochondrial haplogroup; mtDNA; nephropathy; glycemic control

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Diaz-Morales, N.; Lopez-Domenech, S.; Iannantuoni, F.; Lopez-Gallardo, E.; Sola, E.; Morillas, C.; Rocha, M.; Ruiz-Pesini, E.; Victor, V.M. Mitochondrial DNA Haplogroup JT is Related to Impaired Glycaemic Control and Renal Function in Type 2 Diabetic Patients. J. Clin. Med. 2018, 7, 220.

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