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J. Clin. Med. 2018, 7(3), 51; https://doi.org/10.3390/jcm7030051

Disease and Treatment-Related Sequelae in Patients with Complex Jugulotympanic Paraganglioma

1
Neurosurgical Department, Klinikum Dortmund, 44145 Dortmund, Germany
2
Department of Radiology and Neuroradiology, Klinikum Dortmund, 44145 Dortmund, Germany
3
Department of ENT, Klinikum Dortmund, 44145 Dortmund, Germany
*
Author to whom correspondence should be addressed.
Received: 14 February 2018 / Revised: 6 March 2018 / Accepted: 8 March 2018 / Published: 10 March 2018
(This article belongs to the Special Issue Pheochromocytoma and Paraganglioma: Research Update)
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Abstract

Background: Jugulotympanic paraganglioma (JTP) are benign, high-vascularized lesions that frequently invade the jugular foramen, temporal bone, the upper neck, and the posterior fossa cavity, resulting in a wide variety of clinical symptoms. Methods: In this retrospective study, we assess the clinical symptoms and discuss the individual multidisciplinary treatment and outcome of 22 patients with JTP. Results: In 12 patients, a hearing deficit was the presenting symptom, whereas pulsatile tinnitus and otalgia were present in six and four patients respectively. Facial nerve involvement was seen in six patients (three HB Grade 1–2 and three HB Grade 4–6). Four patients presented with lower cranial nerve impairment. Rare symptoms were ataxia caused by brainstem compression and papilledema due to cerebral sinus obstruction. A new or worsening of the preoperative facial nerve or lower cranial nerve function occurred in two and four patients respectively. Conclusion: The treatment strategy and the surgical approach for JTP should be tailored to the tumor extension and the patient’s clinical symptoms. View Full-Text
Keywords: jugular foramen; microsurgery; jugulotympanic paraganglioma; facial nerve; lower cranial nerves; internal carotid artery; vertebral artery jugular foramen; microsurgery; jugulotympanic paraganglioma; facial nerve; lower cranial nerves; internal carotid artery; vertebral artery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Harati, A.; Schultheiß, R.; Rohde, S.; Deitmer, T. Disease and Treatment-Related Sequelae in Patients with Complex Jugulotympanic Paraganglioma. J. Clin. Med. 2018, 7, 51.

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