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J. Clin. Med. 2017, 6(5), 49; doi:10.3390/jcm6050049

Serum Profiles of Cytokines in Behcet’s Disease

1
Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan 4515613191, Iran
2
Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran 3439123900, Iran
3
Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan 7797845157, Iran
4
Zanjan Applied Pharmacology Research Center, Zanjan University of Medical Sciences, Zanjan 4513956184, Iran
5
Department of Pharmacotherapy, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan 4513956184, Iran
*
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel Andrès
Received: 23 January 2017 / Revised: 14 April 2017 / Accepted: 17 April 2017 / Published: 2 May 2017
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Abstract

Introduction: Behcet’s disease (BD) is a chronic systemic autoinflammatory vasculitis which is handled by the variety of proteins like cytokines. Therefore, cytokines are considered as one of the prototypic factors during inflammatory responses of BD. Consequently, the present study was designed for evaluation of cytokine profiles in Iranian BD cases, including those with and without uveitis. Materials and Method: All cases were divided into three groups based on ophthalmologic exam results: BD with uveitis, BD without uveitis, and recovered uveitis BD. Cases with a history of BD recovery were placed in the group of recovered uveitis. The patients with infectious uveitis as well as other collagen vascular diseases and patients who have used biologics to treat ocular immune-mediated diseases were excluded. Finally, after venous blood sampling, levels of cytokines were quantified and statistical approaches were performed for measurements. Results: Enrolled cases were divided to 26 patients with active uveitis, 25 patients with recovered uveitis and 24 patients without uveitis and interestingly, just IL-2 was the only cytokine that showed statistical difference in patients with BD uveitis in comparison with other groups (pvalue = 0.02). The pair wise comparison showed a significant difference between the patients with and without uveitis groups (pvalue = 0.004) as well as patients with uveitis and recovered uveitis groups (pvalue = 0.002). Discussion: Significant elevation of IL-2 in patients with uveitis (in comparison with recovered or without uveitis cases) demonstrates that it may be one of the main proteins that enroll in the pathophysiology of BD uveitis and may be considered as a new target for refractory disease therapies. Studies with larger samples can help to obtain more accurate conclusions. View Full-Text
Keywords: cytokines; Behcet’s disease; uveitis cytokines; Behcet’s disease; uveitis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sadeghi, A.; Davatchi, F.; Shahram, F.; Karimimoghadam, A.; Alikhani, M.; Pezeshgi, A.; Mazloomzadeh, S.; Sadeghi-Abdollahi, B.; Asadi-Khiavi, M. Serum Profiles of Cytokines in Behcet’s Disease. J. Clin. Med. 2017, 6, 49.

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