Next Article in Journal
Mitochondrial Modification Techniques and Ethical Issues
Next Article in Special Issue
In Vitro and In Vivo Effects of Gracilaria verrucosa Extracts on Osteoclast Differentiation
Previous Article in Journal / Special Issue
Role of Protein Phosphatase 2A in Osteoblast Differentiation and Function
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
J. Clin. Med. 2017, 6(3), 24; doi:10.3390/jcm6030024

The Roles of Histone Demethylase Jmjd3 in Osteoblast Differentiation and Apoptosis

Department of Endodontics, School of Stomatology, China Medical University, Shenyang 110002, China
*
Author to whom correspondence should be addressed.
Academic Editor: Hirohiko Okamura
Received: 29 December 2016 / Revised: 2 February 2017 / Accepted: 6 February 2017 / Published: 23 February 2017
(This article belongs to the Special Issue Bone Cell Biology and Transcriptional Regulation)
View Full-Text   |   Download PDF [374 KB, uploaded 23 February 2017]   |  

Abstract

Posttranslational modifications including histone methylation regulate gene transcription through directly affecting the structure of chromatin. Trimethylation of histone 3 lysine 27 (H3K27me3) is observed at the promoters of a wide variety of important genes, especially for mammalian development, and contributes to gene silencing. Demethylase Jumonji domain-containing 3 (Jmjd3) catalyzes the transition of H3K27me3 to H3K27me1, therefore from a repressive to an active status of gene expression. Jmjd3 plays important roles in cell differentiation, inflammation, and tumorigenesis by targeting distinct transcription factors. In this review, we summarize the pivotal roles of Jmjd3 in maintaining skeletal homeostasis through regulating osteoblast differentiation, maturation, and apoptosis. View Full-Text
Keywords: Jmjd3; H3K27me3; osteoblast differentiation; bone formation; osteoblast apoptosis Jmjd3; H3K27me3; osteoblast differentiation; bone formation; osteoblast apoptosis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yang, D.; Yu, B.; Sun, H.; Qiu, L. The Roles of Histone Demethylase Jmjd3 in Osteoblast Differentiation and Apoptosis. J. Clin. Med. 2017, 6, 24.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top