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Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10
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J. Clin. Med. 2017, 6(2), 13; doi:10.3390/jcm6020013

Mechanisms by Which B Cells and Regulatory T Cells Influence Development of Murine Organ-Specific Autoimmune Diseases

1
Department of Surgery, University of Missouri, Columbia, MO 65212, USA
2
Department of Molecular Microbiology & Immunology, University of Missouri, Columbia, MO 65212, USA
3
Department of Medicine, University of Missouri, Columbia, MO 65212, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Bonnie N. Dittel
Received: 11 November 2016 / Revised: 21 December 2016 / Accepted: 18 January 2017 / Published: 26 January 2017
(This article belongs to the Special Issue B Cells in Autoimmunity)
View Full-Text   |   Download PDF [1390 KB, uploaded 26 January 2017]   |  

Abstract

Experiments with B cell-deficient (B−/−) mice indicate that a number of autoimmune diseases require B cells in addition to T cells for their development. Using B−/− Non-obese diabetic (NOD) and NOD.H-2h4 mice, we demonstrated that development of spontaneous autoimmune thyroiditis (SAT), Sjogren’s syndrome and diabetes do not develop in B−/− mice, whereas all three diseases develop in B cell-positive wild-type (WT) mice. B cells are required early in life, since reconstitution of adult mice with B cells or autoantibodies did not restore their ability to develop disease. B cells function as important antigen presenting cells (APC) to initiate activation of autoreactive CD4+ effector T cells. If B cells are absent or greatly reduced in number, other APC will present the antigen, such that Treg are preferentially activated and effector T cells are not activated. In these situations, B−/− or B cell-depleted mice develop the autoimmune disease when T regulatory cells (Treg) are transiently depleted. This review focuses on how B cells influence Treg activation and function, and briefly considers factors that influence the effectiveness of B cell depletion for treatment of autoimmune diseases. View Full-Text
Keywords: B cells; autoimmunity; regulatory T cells; effector T cells; APC B cells; autoimmunity; regulatory T cells; effector T cells; APC
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Ellis, J.S.; Braley-Mullen, H. Mechanisms by Which B Cells and Regulatory T Cells Influence Development of Murine Organ-Specific Autoimmune Diseases. J. Clin. Med. 2017, 6, 13.

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