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J. Clin. Med. 2017, 6(1), 7; doi:10.3390/jcm6010007

Stromal Modulators of TGF-β in Cancer

1
Metastasis Research Laboratory, GIGA-Cancer, University of Liege, 4000 Liege, Belgium
2
Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université Montpellier, Institut Régional du Cancer de Montpellier, 34298 Montpellier, France
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Emanuel F. Petricoin
Received: 4 November 2016 / Revised: 19 December 2016 / Accepted: 23 December 2016 / Published: 6 January 2017
(This article belongs to the Special Issue Biological and Clinical Aspects of TGF-beta in Carcinogenesis)
View Full-Text   |   Download PDF [2123 KB, uploaded 6 January 2017]   |  

Abstract

Transforming growth factor-β (TGF-β) is an intriguing cytokine exhibiting dual activities in malignant disease. It is an important mediator of cancer invasion, metastasis and angiogenesis, on the one hand, while it exhibits anti-tumor functions on the other hand. Elucidating the precise role of TGF-β in malignant development and progression requires a better understanding of the molecular mechanisms involved in its tumor suppressor to tumor promoter switch. One important aspect of TGF-β function is its interaction with proteins within the tumor microenvironment. Several stromal proteins have the natural ability to interact and modulate TGF-β function. Understanding the complex interplay between the TGF-β signaling network and these stromal proteins may provide greater insight into the development of novel therapeutic strategies that target the TGF-β axis. The present review highlights our present understanding of how stroma modulates TGF-β activity in human cancers. View Full-Text
Keywords: cancer-associated fibroblasts; proteases; proteoglycans; TGF-β; stroma cancer-associated fibroblasts; proteases; proteoglycans; TGF-β; stroma
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Costanza, B.; Umelo, I.A.; Bellier, J.; Castronovo, V.; Turtoi, A. Stromal Modulators of TGF-β in Cancer. J. Clin. Med. 2017, 6, 7.

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