Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10
AbstractIn the past two decades it has become clear that in addition to antigen presentation and antibody production B cells play prominent roles in immune regulation. While B cell-derived IL-10 has garnered much attention, B cells also effectively regulate inflammation by a variety of IL-10-independent mechanisms. B cell regulation has been studied in both autoimmune and inflammatory diseases. While collectively called regulatory B cells (Breg), no definitive phenotype has emerged for B cells with regulatory potential. This has made their study challenging and thus unique B cell regulatory mechanisms have emerged in a disease-dependent manner. Thus to harness the therapeutic potential of Breg, further studies are needed to understand how they emerge and are induced to evoke their regulatory activities. View Full-Text
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Ray, A.; Dittel, B.N. Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10. J. Clin. Med. 2017, 6, 12.
Ray A, Dittel BN. Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10. Journal of Clinical Medicine. 2017; 6(1):12.Chicago/Turabian Style
Ray, Avijit; Dittel, Bonnie N. 2017. "Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10." J. Clin. Med. 6, no. 1: 12.
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