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J. Clin. Med. 2017, 6(1), 12; doi:10.3390/jcm6010012

Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10

1
Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA
2
Oncology Discovery, AbbVie Inc., North Chicago, IL 60064, USA
3
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel Andrès
Received: 20 December 2016 / Revised: 17 January 2017 / Accepted: 19 January 2017 / Published: 23 January 2017
(This article belongs to the Special Issue B Cells in Autoimmunity)
View Full-Text   |   Download PDF [192 KB, uploaded 23 January 2017]

Abstract

In the past two decades it has become clear that in addition to antigen presentation and antibody production B cells play prominent roles in immune regulation. While B cell-derived IL-10 has garnered much attention, B cells also effectively regulate inflammation by a variety of IL-10-independent mechanisms. B cell regulation has been studied in both autoimmune and inflammatory diseases. While collectively called regulatory B cells (Breg), no definitive phenotype has emerged for B cells with regulatory potential. This has made their study challenging and thus unique B cell regulatory mechanisms have emerged in a disease-dependent manner. Thus to harness the therapeutic potential of Breg, further studies are needed to understand how they emerge and are induced to evoke their regulatory activities. View Full-Text
Keywords: B cell; immune regulation; autoimmunity; inflammation B cell; immune regulation; autoimmunity; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ray, A.; Dittel, B.N. Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10. J. Clin. Med. 2017, 6, 12.

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