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J. Clin. Med. 2017, 6(1), 11; doi:10.3390/jcm6010011

TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research

1
Research Program for Omics-based Medical Science, Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
2
Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Andrei Turtoi
Received: 17 October 2016 / Revised: 31 December 2016 / Accepted: 16 January 2017 / Published: 18 January 2017
(This article belongs to the Special Issue Biological and Clinical Aspects of TGF-beta in Carcinogenesis)
View Full-Text   |   Download PDF [589 KB, uploaded 18 January 2017]   |  

Abstract

Transforming growth factor (TGF)-β superfamily proteins have many important biological functions, including regulation of tissue differentiation, cell proliferation, and migration in both normal and cancer cells. Many studies have reported that TGF-β signaling is associated with disease progression and therapeutic resistance in several cancers. Similarly, TGF-β-induced protein (TGFBI)—a downstream component of the TGF-β signaling pathway—has been shown to promote and/or inhibit cancer. Here, we review the state of basic and clinical research on the roles of TGF-β and TGFBI in gastrointestinal cancers. View Full-Text
Keywords: TGF-β signaling; TGFBI; gastrointestinal cancer; EMT; tumor promoter; tumor suppressor TGF-β signaling; TGFBI; gastrointestinal cancer; EMT; tumor promoter; tumor suppressor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yokobori, T.; Nishiyama, M. TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research. J. Clin. Med. 2017, 6, 11.

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