EMT in Breast Carcinoma—A Review
AbstractThe epithelial to mesenchymal transition (EMT) is a cellular program that is involved in embryonic development; wound healing, but also in tumorigenesis. Breast carcinoma (BC) is the most common cancer in women worldwide, and the majority of deaths (90%) are caused by invasion and metastasis. The EMT plays an important role in invasion and subsequent metastasis. Several distinct biological events integrate a cascade that leads not only to a change from an epithelial to mesenchymal phenotype, but allows for detachment, migration, invasion and ultimately, colonization of a second site. Understanding the biological intricacies of the EMT may provide important insights that lead to the development of therapeutic targets in pre-invasive and invasive breast cancer, and could be used as biomarkers identifying tumor subsets with greater chances of recurrence, metastasis and therapeutic resistance leading to death. View Full-Text
Share & Cite This Article
Felipe Lima, J.; Nofech-Mozes, S.; Bayani, J.; Bartlett, J.M.S. EMT in Breast Carcinoma—A Review. J. Clin. Med. 2016, 5, 65.
Felipe Lima J, Nofech-Mozes S, Bayani J, Bartlett JMS. EMT in Breast Carcinoma—A Review. Journal of Clinical Medicine. 2016; 5(7):65.Chicago/Turabian Style
Felipe Lima, Joema; Nofech-Mozes, Sharon; Bayani, Jane; Bartlett, John M.S. 2016. "EMT in Breast Carcinoma—A Review." J. Clin. Med. 5, no. 7: 65.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.