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J. Clin. Med. 2016, 5(7), 60; doi:10.3390/jcm5070060

The Impact of Remote Ischemic Preconditioning on Arterial Stiffness and Heart Rate Variability in Patients with Angina Pectoris

Department of Internal Diseases, Bashkir State Medical University, Ufa, 450000, Russia
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Author to whom correspondence should be addressed.
Academic Editor: Lindsay Brown
Received: 26 March 2016 / Revised: 8 June 2016 / Accepted: 17 June 2016 / Published: 23 June 2016
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Abstract

Remote ischemic preconditioning (RIPC) is the set of ischemia episodes that protects against subsequent periods of prolonged ischemia through the cascade of adaptive responses; however, the mechanisms of RIPC are not entirely clear. Here, we aimed to study the impact of RIPC in patients with stable angina pectoris and compare it with healthy individuals with respect to arterial stiffness and heart rate variability. In the randomized, sham-controlled, crossover blind design study, a group of 30 coronary heart disease (CHD) patients (63.9 ± 1.6 years) with stable angina pectoris NYHA II-III and a control group of 20 healthy individuals (58.2 ± 2.49) were both randomly allocated for remote RIPC or sham RIPC. Arterial stiffness, pulse wave velocity (Spygmacor, Australia), and heart rate variability (HRV) were recorded before and after the procedure followed by the crossover examination. In the group of healthy individuals, RIPC showed virtually no impact on the cardiovascular parameters, while, in the CHD group, the systolic and central systolic blood pressure, central pulse pressure, and augmentation decreased, and total power of HRV improved. We conclude that ischemic preconditioning reduces not only systolic blood pressure, but also reduces central systolic blood pressure and improves arterial compliance and heart rate modulation reserve, which may be associated with the antianginal effect of preconditioning. View Full-Text
Keywords: RIPC; angina pectoris; arterial stiffness; heart rate variability RIPC; angina pectoris; arterial stiffness; heart rate variability
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MDPI and ACS Style

Zagidullin, N.; Scherbakova, E.; Safina, Y.; Zulkarneev, R.; Zagidullin, S. The Impact of Remote Ischemic Preconditioning on Arterial Stiffness and Heart Rate Variability in Patients with Angina Pectoris. J. Clin. Med. 2016, 5, 60.

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