Next Article in Journal
The Impact of Remote Ischemic Preconditioning on Arterial Stiffness and Heart Rate Variability in Patients with Angina Pectoris
Previous Article in Journal
Tele-Operated Echography and Remote Guidance for Performing Tele-Echography on Geographically Isolated Patients
Previous Article in Special Issue
Considering Exosomal miR-21 as a Biomarker for Cancer
Article Menu

Export Article

Open AccessReview
J. Clin. Med. 2016, 5(6), 59; doi:10.3390/jcm5060059

The Role of microRNAs in the Diagnosis and Treatment of Pancreatic Adenocarcinoma

Department of Internal Medicine, School of Medicine, Wayne State University, Detroit, MI 48201, USA
Department of Oncology, Karmanos Cancer institute, Wayne State University, Detroit, MI 48201, USA
Author to whom correspondence should be addressed.
Academic Editors: Takahiro Ochiya and Ryou-u Takahashi
Received: 31 March 2016 / Revised: 8 June 2016 / Accepted: 13 June 2016 / Published: 16 June 2016
(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers)
View Full-Text   |   Download PDF [225 KB, uploaded 16 June 2016]


Pancreatic ductal adenocarcinoma (PDAC) remains a very challenging malignancy. Disease is diagnosed in an advanced stage in the vast majority of patients, and PDAC cells are often resistant to conventional cytotoxic drugs. Targeted therapies have made no progress in the management of this disease, unlike other cancers. microRNAs (miRs) are small non-coding RNAs that regulate the expression of multitude number of genes by targeting their 3′-UTR mRNA region. Aberrant expression of miRNAs has been linked to the development of various malignancies, including PDAC. In PDAC, a series of miRs have been defined as holding promise for early diagnostics, as indicators of therapy resistance, and even as markers for therapeutic response in patients. In this mini-review, we present an update on the various different miRs that have been defined in PDAC biology. View Full-Text
Keywords: pancreatic ductal adenocarcinoma; micro-RNA; biology; diagnosis; therapy; prognosis pancreatic ductal adenocarcinoma; micro-RNA; biology; diagnosis; therapy; prognosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Diab, M.; Muqbil, I.; Mohammad, R.M.; Azmi, A.S.; Philip, P.A. The Role of microRNAs in the Diagnosis and Treatment of Pancreatic Adenocarcinoma. J. Clin. Med. 2016, 5, 59.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top