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J. Clin. Med. 2016, 5(6), 59; doi:10.3390/jcm5060059

The Role of microRNAs in the Diagnosis and Treatment of Pancreatic Adenocarcinoma

1
Department of Internal Medicine, School of Medicine, Wayne State University, Detroit, MI 48201, USA
2
Department of Oncology, Karmanos Cancer institute, Wayne State University, Detroit, MI 48201, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Takahiro Ochiya and Ryou-u Takahashi
Received: 31 March 2016 / Revised: 8 June 2016 / Accepted: 13 June 2016 / Published: 16 June 2016
(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers)
View Full-Text   |   Download PDF [225 KB, uploaded 16 June 2016]

Abstract

Pancreatic ductal adenocarcinoma (PDAC) remains a very challenging malignancy. Disease is diagnosed in an advanced stage in the vast majority of patients, and PDAC cells are often resistant to conventional cytotoxic drugs. Targeted therapies have made no progress in the management of this disease, unlike other cancers. microRNAs (miRs) are small non-coding RNAs that regulate the expression of multitude number of genes by targeting their 3′-UTR mRNA region. Aberrant expression of miRNAs has been linked to the development of various malignancies, including PDAC. In PDAC, a series of miRs have been defined as holding promise for early diagnostics, as indicators of therapy resistance, and even as markers for therapeutic response in patients. In this mini-review, we present an update on the various different miRs that have been defined in PDAC biology. View Full-Text
Keywords: pancreatic ductal adenocarcinoma; micro-RNA; biology; diagnosis; therapy; prognosis pancreatic ductal adenocarcinoma; micro-RNA; biology; diagnosis; therapy; prognosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Diab, M.; Muqbil, I.; Mohammad, R.M.; Azmi, A.S.; Philip, P.A. The Role of microRNAs in the Diagnosis and Treatment of Pancreatic Adenocarcinoma. J. Clin. Med. 2016, 5, 59.

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