Next Article in Journal
Managing Status Epilepticus in the Older Adult
Previous Article in Journal
Tumor Budding: The Name is EMT. Partial EMT.
Previous Article in Special Issue
Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
Article Menu

Export Article

Open AccessReview
J. Clin. Med. 2016, 5(5), 52; doi:10.3390/jcm5050052

MicroRNAs in the Evaluation and Potential Treatment of Liver Diseases

1
Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota Medical School, Veterans of Foreign Wars Cancer Research Center, 406 Harvard Street, S.E., Minneapolis, MN 55455, USA
2
Department of Genetics, Cell Biology and Development, University of Minnesota Medical School, Veterans of Foreign Wars Cancer Research Center, 406 Harvard Street, S.E., Minneapolis, MN 55455, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Ryou-u Takahashi
Received: 20 February 2016 / Revised: 18 April 2016 / Accepted: 25 April 2016 / Published: 10 May 2016
(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers for Liver Diseases)
View Full-Text   |   Download PDF [1906 KB, uploaded 12 May 2016]   |  

Abstract

Acute and chronic liver disease continue to result in significant morbidity and mortality of patients, along with increasing burden on their families, society and the health care system. This in part is due to increased incidence of liver disease associated factors such as metabolic syndrome; improved survival of patients with chronic predisposing conditions such as HIV; as well as advances in the field of transplantation and associated care leading to improved survival. The fact that one disease can result in different manifestations and outcomes highlights the need for improved understanding of not just genetic phenomenon predisposing to a condition, but additionally the role of epigenetic and environmental factors leading to the phenotype of the disease. It is not surprising that providers continue to face daily challenges pertaining to diagnostic accuracy, prognostication of disease severity, progression, and response to therapies. A number of these challenges can be addressed by incorporating a personalized approach of management to the current paradigm of care. Recent advances in the fields of molecular biology and genetics have paved the way to more accurate, individualized and precise approach to caring for liver disease. The study of microRNAs and their role in both healthy and diseased livers is one example of such advances. As these small, non-coding RNAs work on fine-tuning of cellular activities and organ function in a dynamic and precise fashion, they provide us a golden opportunity to advance the field of hepatology. The study of microRNAs in liver disease promises tremendous improvement in hepatology and is likely to lay the foundation towards a personalized approach in liver disease. View Full-Text
Keywords: acute liver failure; biogenesis; epigenetics; hepatitis; hepatocellular carcinoma; liver diseases; liver regeneration; metabolic liver diseases; microRNAs; NAFLD; NASH; personalized medicine; non-coding RNAs; partial hepatectomy; systems biology acute liver failure; biogenesis; epigenetics; hepatitis; hepatocellular carcinoma; liver diseases; liver regeneration; metabolic liver diseases; microRNAs; NAFLD; NASH; personalized medicine; non-coding RNAs; partial hepatectomy; systems biology
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mahgoub, A.; Steer, C.J. MicroRNAs in the Evaluation and Potential Treatment of Liver Diseases. J. Clin. Med. 2016, 5, 52.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top