Next Article in Journal / Special Issue
Effect of Cigarette Smoking on Epithelial to Mesenchymal Transition (EMT) in Lung Cancer
Previous Article in Journal
Considering Exosomal miR-21 as a Biomarker for Cancer
Previous Article in Special Issue
Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks
Article Menu

Export Article

Open AccessReview
J. Clin. Med. 2016, 5(4), 43; doi:10.3390/jcm5040043

EMT Involved in Migration of Stem/Progenitor Cells for Pituitary Development and Regeneration

1
Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University, Kanagawa 214-8571, Japan
2
Institute of Reproduction and Endocrinology, Meiji University, Kanagawa 214-8571, Japan
3
Division of Life Science, Graduate School of Agriculture, Meiji University, Kanagawa 214-8571, Japan
4
Department of Life Science, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: David A. Brenner, Tatiana Kisseleva and Jonas Fuxe
Received: 4 December 2015 / Revised: 24 March 2016 / Accepted: 29 March 2016 / Published: 6 April 2016
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
View Full-Text   |   Download PDF [1845 KB, uploaded 6 April 2016]   |  

Abstract

Epithelial–mesenchymal transition (EMT) and cell migration are important processes in embryonic development of many tissues as well as oncogenesis. The pituitary gland is a master endocrine tissue and recent studies indicate that Sox2-expressing stem/progenitor cells actively migrate and develop this tissue during embryogenesis. Notably, although migration activity of stem/progenitor cells in the postnatal period seems to be reduced compared to that in the embryonic period, it is hypothesized that stem/progenitor cells in the adult pituitary re-migrate from their microenvironment niche to contribute to the regeneration system. Therefore, elucidation of EMT in the pituitary stem/progenitor cells will promote understanding of pituitary development and regeneration, as well as diseases such as pituitary adenoma. In this review, so as to gain more insights into the mechanisms of pituitary development and regeneration, we summarize the EMT in the pituitary by focusing on the migration of pituitary stem/progenitor cells during both embryonic and postnatal organogenesis. View Full-Text
Keywords: pituitary development; stem/progenitor cell niche; cell regeneration; EMT; migration pituitary development; stem/progenitor cell niche; cell regeneration; EMT; migration
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yoshida, S.; Kato, T.; Kato, Y. EMT Involved in Migration of Stem/Progenitor Cells for Pituitary Development and Regeneration. J. Clin. Med. 2016, 5, 43.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top