Next Article in Journal
Considering Exosomal miR-21 as a Biomarker for Cancer
Next Article in Special Issue
EMT Involved in Migration of Stem/Progenitor Cells for Pituitary Development and Regeneration
Previous Article in Journal / Special Issue
Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition
Article Menu

Export Article

Open AccessReview
J. Clin. Med. 2016, 5(4), 41; doi:10.3390/jcm5040041

Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks

Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jane Grant-Kels
Received: 20 November 2015 / Revised: 31 January 2016 / Accepted: 21 March 2016 / Published: 28 March 2016
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
View Full-Text   |   Download PDF [1662 KB, uploaded 28 March 2016]   |  

Abstract

Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor-β (TGF-β), Sonic Hedgehog (SHH), and WNT pathways. These signaling pathways crosstalk to each other and converge to key transcription factors (e.g., SNAIL1) to initialize and maintain the process of EMT. The functional roles of multi-signaling pathway crosstalks in EMT are sophisticated and, thus, remain to be explored. In this review, we focused on three major signal transduction pathways that promote or regulate EMT in carcinoma. We discussed the network structures, and provided a brief overview of the current therapy strategies and drug development targeted to these three signal transduction pathways. Finally, we highlighted systems biology approaches that can accelerate the process of deconstructing complex networks and drug discovery. View Full-Text
Keywords: signaling transduction pathways; EMT; TGF-β; SHH; WNT; modeling signaling transduction pathways; EMT; TGF-β; SHH; WNT; modeling
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhang, J.; Tian, X.-J.; Xing, J. Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks. J. Clin. Med. 2016, 5, 41.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top