Next Article in Journal
MicroRNA In Lung Cancer: Novel Biomarkers and Potential Tools for Treatment
Previous Article in Journal
Omega-3 Fatty Acids in Modern Parenteral Nutrition: A Review of the Current Evidence
Article Menu

Export Article

Open AccessArticle
J. Clin. Med. 2016, 5(3), 35; doi:10.3390/jcm5030035

Kidney Function as a Determinant of HDL and Triglyceride Concentrations in the Australian Population

Royal Hobart Hospital, University of Tasmania, GPO Box-1061, Hobart 7000, Australia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Jane Grant-Kels
Received: 31 December 2015 / Revised: 29 February 2016 / Accepted: 2 March 2016 / Published: 8 March 2016
View Full-Text   |   Download PDF [1097 KB, uploaded 8 March 2016]   |  

Abstract

Background: Chronic kidney disease (CKD) is a potent risk factor for cardiovascular disease (CVD). CVD risk increases in a stepwise manner with increasing kidney impairment and is significantly reduced by kidney transplantation, suggesting a causal relationship. Dyslipidemia, a well recognised CVD risk factor, is highly prevalent in CKD. While dyslipidemia is a risk factor for CKD, kidney impairment can also induce a dyslipidemic state that may contribute to the excess burden of CVD in CKD. We utilised a multipronged approach to determine whether a causal relationship exists. Materials and Methods: Retrospective case-control analysis of 816 patients admitted to the Royal Hobart Hospital in 2008–2009 with different degrees of kidney impairment and retrospective before-after cohort analysis of 60 patients who received a transplanted kidney between 1999 and 2009. Results: Decreased estimated GFR (eGFR) was independently associated with decreased high density lipoprotein (HDL, p < 0.0001) and increased triglyceride concentrations (p < 0.01) in multivariate analysis. There was no significant relationship between eGFR and low density lipoprotein (LDL) or total cholesterol in multivariate analysis. Kidney transplantation increased HDL (p < 0.0001) and decreased triglyceride (p = 0.007) concentration, whereas there was no significant change in LDL and total cholesterol. These effects were dependent on maintenance of graft function, statin therapy (those who were on) if graft failure occurred then HDL again decreased and triglycerides increased. Conclusions: Kidney transplantation ameliorated alterations in plasma lipoprotein profile associated with kidney impairment, an effect that was dependent on the maintenance of graft function. These data suggest that kidney function is a determinant of HDL and triglyceride concentrations in patients with CKD. View Full-Text
Keywords: CKD; CVD; HDL; kidney transplantation; lipids; triglycerides CKD; CVD; HDL; kidney transplantation; lipids; triglycerides
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Thompson, M.; Ray, U.; Yu, R.; Hudspeth, A.; Smillie, M.; Jordan, N.; Bartle, J. Kidney Function as a Determinant of HDL and Triglyceride Concentrations in the Australian Population. J. Clin. Med. 2016, 5, 35.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top