Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion
AbstractThe Protein Kinase D (PKD) isoforms PKD1, PKD2, and PKD3 are effectors of the novel Protein Kinase Cs (nPKCs) and diacylglycerol (DAG). PKDs impact diverse biological processes like protein transport, cell migration, proliferation, epithelial to mesenchymal transition (EMT) and apoptosis. PKDs however, have distinct effects on these functions. While PKD1 blocks EMT and cell migration, PKD2 and PKD3 tend to drive both processes. Given the importance of EMT and cell migration to the initiation and progression of various malignancies, abnormal expression of PKDs has been reported in multiple types of cancers, including breast, pancreatic and prostate cancer. In this review, we discuss how EMT and cell migration are regulated by PKD isoforms and the significance of this regulation in the context of cancer development. View Full-Text
Share & Cite This Article
Durand, N.; Borges, S.; Storz, P. Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion. J. Clin. Med. 2016, 5, 20.
Durand N, Borges S, Storz P. Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion. Journal of Clinical Medicine. 2016; 5(2):20.Chicago/Turabian Style
Durand, Nisha; Borges, Sahra; Storz, Peter. 2016. "Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion." J. Clin. Med. 5, no. 2: 20.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.