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J. Clin. Med. 2016, 5(12), 107; doi:10.3390/jcm5120107

Inebilizumab, a B Cell-Depleting Anti-CD19 Antibody for the Treatment of Autoimmune Neurological Diseases: Insights from Preclinical Studies

1
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
2
Department of Project Management, MedImmune, Gaithersburg, MD 20878, USA
3
Department of Oncology Research, MedImmune, Gaithersburg, MD 20878, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Bonnie N. Dittel
Received: 2 October 2016 / Revised: 14 November 2016 / Accepted: 17 November 2016 / Published: 24 November 2016
(This article belongs to the Special Issue B Cells in Autoimmunity)
View Full-Text   |   Download PDF [222 KB, uploaded 24 November 2016]

Abstract

Exaggerated or inappropriate responses by B cells are an important feature in many types of autoimmune neurological diseases. The recent success of B-cell depletion in the treatment of multiple sclerosis (MS) has stimulated the development of novel B-cell-targeting therapies with the potential for improved efficacy. CD19 has emerged as a promising target for the depletion of B cells as well as CD19-positive plasmablasts and plasma cells. Inebilizumab (MEDI-551), an anti-CD19 antibody with enhanced antibody-dependent cell-mediated cytotoxicity against B cells, is currently being evaluated in MS and neuromyelitis optica. This review discusses the role of B cells in autoimmune neurological disorders, summarizes the development of inebilizumab, and analyzes the recent results for inebilizumab treatment in an autoimmune encephalitis mouse model. The novel insights obtained from these preclinical studies can potentially guide future investigation of inebilizumab in patients. View Full-Text
Keywords: CD19; B-cell depletion; autoimmunity; multiple sclerosis; neuromyelitis optica CD19; B-cell depletion; autoimmunity; multiple sclerosis; neuromyelitis optica
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chen, D.; Gallagher, S.; Monson, N.L.; Herbst, R.; Wang, Y. Inebilizumab, a B Cell-Depleting Anti-CD19 Antibody for the Treatment of Autoimmune Neurological Diseases: Insights from Preclinical Studies. J. Clin. Med. 2016, 5, 107.

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