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J. Clin. Med. 2016, 5(11), 100; doi:10.3390/jcm5110100

The Future Prospects of Immune Therapy in Gastric and Esophageal Adenocarcinoma

1
Department of Hematology and Oncology, Winship Cancer Institute, Emory University, 1365 Clifton Rd NE, Atlanta, GA 30322, USA
2
Department of Medicine, Balamand University, Beirut 1300, Lebanon
3
Department of Internal Medicine, Emory University, Atlanta, GA 30322, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 4 August 2016 / Revised: 2 November 2016 / Accepted: 2 November 2016 / Published: 14 November 2016
(This article belongs to the Special Issue Updates on Treatment of Esophageal Cancer)
View Full-Text   |   Download PDF [452 KB, uploaded 14 November 2016]   |  

Abstract

The prognosis of esophageal cancers is poor and novel approaches are urgently needed. Despite improvements in outcomes with transtuzumab and ramucirumab, these improvements added an average of only 2 to 3 months with a median overall survival reported to be around 1 year. Comprehensive genomic sequencing has defined some molecular alterations with potential targets, but the majority of patients still do not benefit from druggable targets. Breakthroughs in immune checkpoint blockade have provided new therapeutic options in many cancers. Programmed death ligand 1 (PDL1) overexpression, a possible biomarker predicting response to immune checkpoint inhibitors, approaches forty percent in esophageal and gastric cancers. Translational and molecular studies have shown that esophageal cancers are possible candidate malignancies for immune checkpoint inhibition. In this review, we plan to highlight the mechanisms, preclinical, and early clinical data that provide insight on the role of immune therapeutics in esophageal cancers. View Full-Text
Keywords: esophageal cancer; immune therapy; progress esophageal cancer; immune therapy; progress
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shaib, W.L.; Nammour, J.P.A.; Gill, H.; Mody, M.; Saba, N.F. The Future Prospects of Immune Therapy in Gastric and Esophageal Adenocarcinoma. J. Clin. Med. 2016, 5, 100.

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