Next Article in Journal / Special Issue
Identification of Recurrence-Related microRNAs from Bone Marrow in Hepatocellular Carcinoma Patients
Previous Article in Journal / Special Issue
Role of MicroRNAs-221/222 in Digestive Systems
Article Menu

Export Article

Open AccessReview
J. Clin. Med. 2015, 4(8), 1578-1599; doi:10.3390/jcm4081578

MicroRNAs and Growth Factors: An Alliance Propelling Tumor Progression

Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
Current Address: Genetic Institute, Tel Aviv Medical Centre, Tel Aviv 64239, Israel
*
Author to whom correspondence should be addressed.
Academic Editors: Takahiro Ochiya and Ryou-u Takahashi
Received: 2 July 2015 / Revised: 30 July 2015 / Accepted: 31 July 2015 / Published: 13 August 2015
(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers)
View Full-Text   |   Download PDF [745 KB, uploaded 13 August 2015]   |  

Abstract

Tumor progression requires cancer cell proliferation, migration, invasion, and attraction of blood and lymph vessels. These processes are tightly regulated by growth factors and their intracellular signaling pathways, which culminate in transcriptional programs. Hence, oncogenic mutations often capture growth factor signaling, and drugs able to intercept the underlying biochemical routes might retard cancer spread. Along with messenger RNAs, microRNAs play regulatory roles in growth factor signaling and in tumor progression. Because growth factors regulate abundance of certain microRNAs and the latter modulate the abundance of proteins necessary for growth factor signaling, the two classes of molecules form a dense web of interactions, which are dominated by a few recurring modules. We review specific examples of the alliance formed by growth factors and microRNAs and refer primarily to the epidermal growth factor (EGF) pathway. Clinical applications of the crosstalk between microRNAs and growth factors are described, including relevance to cancer therapy and to emergence of resistance to specific drugs. View Full-Text
Keywords: cancer therapy; carcinoma; epidermal growth factor (EGF); metastasis; network; receptor tyrosine kinase; signal transduction; transcription cancer therapy; carcinoma; epidermal growth factor (EGF); metastasis; network; receptor tyrosine kinase; signal transduction; transcription
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kedmi, M.; Sas-Chen, A.; Yarden, Y. MicroRNAs and Growth Factors: An Alliance Propelling Tumor Progression. J. Clin. Med. 2015, 4, 1578-1599.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top