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J. Clin. Med. 2015, 4(12), 1960-1976; doi:10.3390/jcm4121952

Claudin 1 in Breast Cancer: New Insights

Department of Pathology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E3P5, Canada
Department of Physiology and Pathophysiology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E0J9, Canada
Department of Biochemistry and Human Genetics, University of Manitoba, Winnipeg, MB R3E0J9, Canada
Author to whom correspondence should be addressed.
Academic Editor: Jane Grant-Kels
Received: 1 October 2015 / Revised: 9 November 2015 / Accepted: 14 November 2015 / Published: 27 November 2015
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
View Full-Text   |   Download PDF [785 KB, uploaded 30 November 2015]   |  


Claudin 1 is a small transmembrane protein responsible for maintaining the barrier function that exists between epithelial cells. A tight junction protein that regulates the paracellular transport of small ions across adjacent cells, claudin 1 maintains cellular polarity and plays a major role in cell-cell communication and epithelial cell homeostasis. Long considered to be a putative tumor suppressor in human breast cancer, new studies suggest a role much more complex. While most invasive breast cancers exhibit a down regulation or absence of claudin 1, some aggressive subtypes that exhibit high claudin 1 levels have now been described. Furthermore, a causal role for claudin 1 in breast cancer progression has recently been demonstrated in some breast cancer cell lines. In this review we highlight new insights into the role of claudin 1 in breast cancer, including its involvement in collective migration and epithelial mesenchymal transition (EMT). View Full-Text
Keywords: claudin 1; breast cancer; EMT; “high claudin”; collective migration; interacting partners claudin 1; breast cancer; EMT; “high claudin”; collective migration; interacting partners

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhou, B.; Moodie, A.; Blanchard, A.A.A.; Leygue, E.; Myal, Y. Claudin 1 in Breast Cancer: New Insights. J. Clin. Med. 2015, 4, 1960-1976.

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