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J. Clin. Med. 2015, 4(1), 172-192; doi:10.3390/jcm4010172

NLRP3 Inflammasome and Pathobiology in AMD

1
Neurovascular Genetics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Lincoln Place Gate, Dublin 2, Ireland
2
Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Lindsay Farrer
Received: 1 October 2014 / Accepted: 19 December 2014 / Published: 14 January 2015
(This article belongs to the Special Issue Age-Related Macular Disease)
View Full-Text   |   Download PDF [326 KB, uploaded 14 January 2015]   |  

Abstract

Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is characterized by a progressive loss of photoreceptors in the macula due to damage to the retinal pigment epithelium (RPE). Clinically, it is manifested by drusen deposition between the RPE and underlying choroid and accumulation of lipofuscin in the RPE. End-stage disease is characterized by geographic atrophy (dry AMD) or choroidal neovascularization (wet AMD). The NLRP3 inflammasome has recently been implicated in the disease pathology. Here we review the current knowledge on the involvement of this multiprotein complex and its effector cytokines interleukin-1β (IL-1β) and IL-18 in AMD progression. We also describe cell death mechanisms that have been proposed to underlie RPE degeneration in AMD and discuss the role of autophagy in the regulation of disease progression. View Full-Text
Keywords: age-related macular degeneration; NLRP3 inflammasome; IL-18; geographic atrophy; choroidal neovascularization; retinal pigment epithelium; pyroptosis; autophagy age-related macular degeneration; NLRP3 inflammasome; IL-18; geographic atrophy; choroidal neovascularization; retinal pigment epithelium; pyroptosis; autophagy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Celkova, L.; Doyle, S.L.; Campbell, M. NLRP3 Inflammasome and Pathobiology in AMD. J. Clin. Med. 2015, 4, 172-192.

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