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J. Clin. Med. 2014, 3(3), 972-985; doi:10.3390/jcm3030972

Fetal Cell Based Prenatal Diagnosis: Perspectives on the Present and Future

DePaul University and Insight Medical Genetics, LLC 680 N, Lake Shore Drive Chicago, IL 60611, USA
Received: 24 April 2014 / Revised: 19 August 2014 / Accepted: 28 August 2014 / Published: 5 September 2014
(This article belongs to the Special Issue Prenatal Genetic Screening and Diagnosis-Part 1)
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Abstract

The ability to capture and analyze fetal cells from maternal circulation or other sources during pregnancy has been a goal of prenatal diagnostics for over thirty years. The vision of replacing invasive prenatal diagnostic procedures with the prospect of having the entire fetal genome in hand non-invasively for chromosomal and molecular studies for both clinical and research use has brought many investigators and innovations into the effort. While the object of this desire, however, has remained elusive, the aspiration for this approach to non-invasive prenatal diagnosis remains and the inquiry has continued. With the advent of screening by cell-free DNA analysis, the standards for fetal cell based prenatal diagnostics have been sharpened. Relevant aspects of the history and the current status of investigations to meet the goal of having an accessible and reliable strategy for capturing and analyzing fetal cells during pregnancy are reviewed. View Full-Text
Keywords: fetal cells; fetal cells in maternal circulation; non-invasive prenatal diagnosis; prenatal diagnostics; transcervical retrieval of fetal cells; fetal cells from maternal blood fetal cells; fetal cells in maternal circulation; non-invasive prenatal diagnosis; prenatal diagnostics; transcervical retrieval of fetal cells; fetal cells from maternal blood
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Fiddler, M. Fetal Cell Based Prenatal Diagnosis: Perspectives on the Present and Future. J. Clin. Med. 2014, 3, 972-985.

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