- freely available
Importance of Beta Cell Function for the Treatment of Type 2 Diabetes
AbstractType 2 diabetes (T2DM) is characterized by insulin resistance and beta cell dysfunction. Recent evidence has emerged that beta cell dysfunction is a common pathogenetic feature of both type 1 and type 2 diabetes, and T2DM never develops without beta cell dysfunction. Therefore, treatment of T2DM should aim to restore beta cell function. Although the treatment of T2DM has greatly improved over the past few decades, remaining issues in the current treatment of T2DM include (1) hypoglycemia; (2) body weight gain; (3) peripheral hyperinsulinemia and (4) postprandial hyperglycemia, which are all associated with inappropriate insulin supplementation, again underpinning the important role of endogenous and physiological insulin secretion in the management of T2DM. This review summarizes the current knowledge on beta cell function in T2DM and discusses the treatment strategy for T2DM in relation to beta cell dysfunction.
Share & Cite This Article
Export to BibTeX | EndNote
MDPI and ACS Style
Saisho, Y. Importance of Beta Cell Function for the Treatment of Type 2 Diabetes. J. Clin. Med. 2014, 3, 923-943.View more citation formats
Saisho Y. Importance of Beta Cell Function for the Treatment of Type 2 Diabetes. Journal of Clinical Medicine. 2014; 3(3):923-943.Chicago/Turabian Style
Saisho, Yoshifumi. 2014. "Importance of Beta Cell Function for the Treatment of Type 2 Diabetes." J. Clin. Med. 3, no. 3: 923-943.