Next Article in Journal / Special Issue
Fetal Aneuploidy Detection by Cell-Free DNA Sequencing for Multiple Pregnancies and Quality Issues with Vanishing Twins
Previous Article in Journal
Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity
Previous Article in Special Issue
Knowledge and Educational Needs about Pre-Implantation Genetic Diagnosis (PGD) among Oncology Nurses
Article Menu

Export Article

Open AccessReview
J. Clin. Med. 2014, 3(2), 663-678; doi:10.3390/jcm3020663

Microarray Technology for the Diagnosis of Fetal Chromosomal Aberrations: Which Platform Should We Use?

1
NE Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Foundation Trust, London, 37 Queen Square, London WC1N 3BH, UK
2
UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
3
University College Hospital NHS Foundation Trust, London NW1 2PG, UK
4
Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 19 February 2014 / Revised: 28 March 2014 / Accepted: 1 April 2014 / Published: 20 June 2014
(This article belongs to the Special Issue Prenatal Genetic Screening and Diagnosis-Part 2)
View Full-Text   |   Download PDF [694 KB, uploaded 20 June 2014]   |  

Abstract

The advantage of microarray (array) over conventional karyotype for the diagnosis of fetal pathogenic chromosomal anomalies has prompted the use of microarrays in prenatal diagnostics. In this review we compare the performance of different array platforms (BAC, oligonucleotide CGH, SNP) and designs (targeted, whole genome, whole genome, and targeted, custom) and discuss their advantages and disadvantages in relation to prenatal testing. We also discuss the factors to consider when implementing a microarray testing service for the diagnosis of fetal chromosomal aberrations.
Keywords: prenatal microarray; implementation; BAC; SNP prenatal microarray; implementation; BAC; SNP
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Karampetsou, E.; Morrogh, D.; Chitty, L. Microarray Technology for the Diagnosis of Fetal Chromosomal Aberrations: Which Platform Should We Use? J. Clin. Med. 2014, 3, 663-678.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top