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J. Clin. Med. 2014, 3(2), 663-678; doi:10.3390/jcm3020663
Review

Microarray Technology for the Diagnosis of Fetal Chromosomal Aberrations: Which Platform Should We Use?

1,†
,
1,†
 and
2,3,4,†,*
Received: 19 February 2014 / Revised: 28 March 2014 / Accepted: 1 April 2014 / Published: 20 June 2014
(This article belongs to the Special Issue Prenatal Genetic Screening and Diagnosis-Part 2)
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Abstract

The advantage of microarray (array) over conventional karyotype for the diagnosis of fetal pathogenic chromosomal anomalies has prompted the use of microarrays in prenatal diagnostics. In this review we compare the performance of different array platforms (BAC, oligonucleotide CGH, SNP) and designs (targeted, whole genome, whole genome, and targeted, custom) and discuss their advantages and disadvantages in relation to prenatal testing. We also discuss the factors to consider when implementing a microarray testing service for the diagnosis of fetal chromosomal aberrations.
Keywords: prenatal microarray; implementation; BAC; SNP prenatal microarray; implementation; BAC; SNP
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Karampetsou, E.; Morrogh, D.; Chitty, L. Microarray Technology for the Diagnosis of Fetal Chromosomal Aberrations: Which Platform Should We Use? J. Clin. Med. 2014, 3, 663-678.

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