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Membranes 2018, 8(1), 2; doi:10.3390/membranes8010002

Novel Blend for Producing Porous Chitosan-Based Films Suitable for Biomedical Applications

1
Chemical and Petrochemicals Engineering Department, Energy, Egypt-Japan University for Science and Technology, Alexandria 21934, Egypt
2
Polymeric Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), Alexandria 21934, Egypt
3
Materials Science Department, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt
*
Author to whom correspondence should be addressed.
Received: 16 August 2017 / Revised: 23 November 2017 / Accepted: 22 December 2017 / Published: 3 January 2018
(This article belongs to the Special Issue Biological, Biomimetic, and Biomedical Applications of Membranes)
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Abstract

In this work, a chitosan–gelatin–ferulic acid blend was used in different ratios for preparing novel films that can be used in biomedical applications. Both acetic and formic acid were tested as solvents for the chitosan–gelatin–ferulic acid blend. Glycerol was tested as a plasticizer. The thickness, mechanical strength, static water contact angle and water uptake of the prepared films were determined. Also, the prepared films were characterized using different analysis techniques such as Fourier transform infrared spectroscopy (FT-IR) analysis, X-ray diffraction (XRD), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). Acetic acid produced continuous compact surfaces that are not recommended for testing in biomedical applications. The plasticized chitosan–gelatin–ferulic acid blend, using formic acid solvent, produced novel hexagonal porous films with a pore size of around 10–14 µm. This blend is recommended for preparing films (scaffolds) for testing in biomedical applications as it has the advantage of a decreased thickness. View Full-Text
Keywords: chitosan–gelatin–ferulic acid blend; ferulic acid crosslinker; hexagonal porous film; biodegradable blend; biomedical film/membrane chitosan–gelatin–ferulic acid blend; ferulic acid crosslinker; hexagonal porous film; biodegradable blend; biomedical film/membrane
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Nady, N.; Kandil, S.H. Novel Blend for Producing Porous Chitosan-Based Films Suitable for Biomedical Applications. Membranes 2018, 8, 2.

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