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Membranes 2017, 7(3), 38; doi:10.3390/membranes7030038

Artificial Lipid Membranes: Past, Present, and Future

1
Laboratory of Simulation of Industrial Processes, Department of Industrial Management and Technology, School of Maritime and Industry, University of Piraeus, 18534 Piraeus, Greece
2
Laboratory of Inorganic & Analytical Chemistry, School of Chemical Engineering, Department of Chemical Sciences, National Technical University of Athens, 15780 Athens, Greece
3
Laboratory of Environmental Chemistry, Department of Chemistry, University of Athens, 15771 Athens, Greece
*
Author to whom correspondence should be addressed.
Received: 14 June 2017 / Revised: 5 July 2017 / Accepted: 20 July 2017 / Published: 26 July 2017
(This article belongs to the Special Issue Supported Lipid Membranes)
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Abstract

The multifaceted role of biological membranes prompted early the development of artificial lipid-based models with a primary view of reconstituting the natural functions in vitro so as to study and exploit chemoreception for sensor engineering. Over the years, a fair amount of knowledge on the artificial lipid membranes, as both, suspended or supported lipid films and liposomes, has been disseminated and has helped to diversify and expand initial scopes. Artificial lipid membranes can be constructed by several methods, stabilized by various means, functionalized in a variety of ways, experimented upon intensively, and broadly utilized in sensor development, drug testing, drug discovery or as molecular tools and research probes for elucidating the mechanics and the mechanisms of biological membranes. This paper reviews the state-of-the-art, discusses the diversity of applications, and presents future perspectives. The newly-introduced field of artificial cells further broadens the applicability of artificial membranes in studying the evolution of life. View Full-Text
Keywords: artificial lipid membranes; liposomes; Langmuir-Blodgett films; tethered membranes; self-assembly; nanoelectrodes; biosensors; drug delivery; ion channel monitoring; artificial cells artificial lipid membranes; liposomes; Langmuir-Blodgett films; tethered membranes; self-assembly; nanoelectrodes; biosensors; drug delivery; ion channel monitoring; artificial cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Siontorou, C.G.; Nikoleli, G.-P.; Nikolelis, D.P.; Karapetis, S.K. Artificial Lipid Membranes: Past, Present, and Future. Membranes 2017, 7, 38.

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