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Membranes 2017, 7(2), 24; doi:10.3390/membranes7020024

The Effect of Thermal Fluctuation on the Receptor-Mediated Adhesion of a Cell Membrane to an Elastic Substrate

Department of Mechanical, Industrial & Systems Engineering, University of Rhode Island, Kingston, RI 02881, USA
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Academic Editor: Shiro Suetsugu
Received: 14 February 2017 / Revised: 14 April 2017 / Accepted: 25 April 2017 / Published: 27 April 2017
(This article belongs to the Special Issue Feature Papers)
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Abstract

Mechanics of the bilayer membrane play an important role in many biological and bioengineering problems such as cell–substrate and cell–nanomaterial interactions. In this work, we study the effect of thermal fluctuation and the substrate elasticity on the cell membrane–substrate adhesion. We model the adhesion of a fluctuating membrane on an elastic substrate as a two-step reaction comprised of the out-of-plane membrane fluctuation and the receptor–ligand binding. The equilibrium closed bond ratio as a function of substrate rigidity was computed by developing a coupled Fourier space Brownian dynamics and Monte Carlo method. The simulation results show that there exists a crossover value of the substrate rigidity at which the closed bond ratio is maximal. View Full-Text
Keywords: cell membrane; fluctuation; Brownian dynamics; Fourier transform; Monte Carlo cell membrane; fluctuation; Brownian dynamics; Fourier transform; Monte Carlo
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Marzban, B.; Yuan, H. The Effect of Thermal Fluctuation on the Receptor-Mediated Adhesion of a Cell Membrane to an Elastic Substrate. Membranes 2017, 7, 24.

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