Next Article in Journal
Separation of Peptides with Forward Osmosis Biomimetic Membranes
Previous Article in Journal
Integration of Methane Steam Reforming and Water Gas Shift Reaction in a Pd/Au/Pd-Based Catalytic Membrane Reactor for Process Intensification
Article Menu

Export Article

Open AccessArticle
Membranes 2016, 6(4), 45; doi:10.3390/membranes6040045

Flux and Passage Enhancement in Hemodialysis by Incorporating Compound Additive into PVDF Polymer Matrix

Institute of Biological and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300387, China
Beijing Origin water membrane technology Co. Ltd., Beijing 101400, China
State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin 300387, China
Xintai Traditional Chinese Medical Hospital, Xintai 271200, China
Xintai Second Peoples Hospital, Xintai 271219, China
Authors to whom correspondence should be addressed.
Academic Editor: Klaus Rätzke
Received: 7 July 2016 / Revised: 18 September 2016 / Accepted: 21 September 2016 / Published: 19 October 2016
(This article belongs to the Section Membrane Preparation and Characterization)
View Full-Text   |   Download PDF [3563 KB, uploaded 19 October 2016]   |  


In this study, Polyvinylidene fluoride (PVDF) hollow fiber hemodialysis membranes were prepared by non-solvent induced phase separation (NIPS) with compound addtive. The compound additive was made with polyvinyl pyrrolidone (PVP) and Poly ethylene glycol (PEG). The results showed that the modified PVDF membrane had better separation performance than virgin PVDF membrane. The UF flux of modified PVDF membrane can reach 684 L·h−1·m−2 and lysozyme (LZM) passage is 72.6% while virgin PVDF membrane is 313 L·h−1·m−2 and 53.2%. At the same time, the biocompatibility of PVDF membranes was also improved. Compared with commercial polysulfone hemodialysis membrane (Fresenius F60S membrane), the modified PVDF membrane had better mechanical and separation performance. The stress and tensile elongation of modified PVDF membrane was 0.94 MPa and 352% while Fresenius F60S membrane was 0.79 MPa and 59%. The LZM passage reached 72.6% while Fresenius F60S membrane was 54.4%. It was proven that the modified PVDF membrane showed better hydrophilicity, antithrombogenicity, less BSA adsorption, and lower hemolytic ratio and adhesion of platelets. Water contact angle and BSA adsorption of the modified PVDF membrane are 38° and 45 mg/m2 while Fresenius F60S membrane are 64° and 235 mg/m2. Prothrombin time (PT) and activated partial thromboplastin time (APTT) of the modified PVDF membrane are 56.5 s and 25.8 s while Fresenius F60S membrane is 35.7 s and 16.6 s. However, further biocompatibility evaluation is needed to obtain a more comprehensive conclusion. View Full-Text
Keywords: PVDF; PVP; PEG; hemodialysis membrane; structure; performance PVDF; PVP; PEG; hemodialysis membrane; structure; performance

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhang, Q.; Lu, X.; Zhang, Q.; Zhang, L.; Li, S.; Liu, S. Flux and Passage Enhancement in Hemodialysis by Incorporating Compound Additive into PVDF Polymer Matrix. Membranes 2016, 6, 45.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Membranes EISSN 2077-0375 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top